Portal de Periódicos da CAPES

Synthesis of (−)‐Okilactomycin by a Prins‐Type Fragment‐Assembly Strategy

2011; Wiley; Volume: 123; Issue: 26 Linguagem: Inglês

10.1002/ange.201102037

1521-3757

Jason M. Tenenbaum, William Morris, Daniel Custar, Karl A. Scheidt,

Microbial Natural Products and Biosynthesis

Eine konvergente Synthese von (−)-Okilactomycin nutzt eine Prins-Maitland-Japp-Cyclisierung zur Verknüpfung zweier komplizierter Zwischenstufen (siehe Schema). Außerdem kam eine hoch diastereoselektive Lewis-Säure-vermittelte Diels-Alder-Reaktion zum Einsatz, und eine Olefin-Ringschlussmetathese ergab den gespannten 11-gliedrigen Makrocyclus. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.