Meet the First Authors
2019; Lippincott Williams & Wilkins; Volume: 124; Issue: 12 Linguagem: Inglês
10.1161/res.0000000000000278
ISSN1524-4571
Tópico(s)Eicosanoids and Hypertension Pharmacology
ResumoHomeCirculation ResearchVol. 124, No. 12Meet the First Authors Free AccessIn BriefPDF/EPUBAboutView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toFree AccessIn BriefPDF/EPUBMeet the First Authors Originally published6 Jun 2019https://doi.org/10.1161/RES.0000000000000278Circulation Research. 2019;124:1680–1682is related toNdufs2, a Core Subunit of Mitochondrial Complex I, Is Essential for Acute Oxygen-Sensing and Hypoxic Pulmonary VasoconstrictionPropentdyopents as Heme Degradation Intermediates Constrict Mouse Cerebral Arterioles and Are Present in the Cerebrospinal Fluid of Patients With Subarachnoid HemorrhageGut Microbial Associations to Plasma Metabolites Linked to Cardiovascular Phenotypes and RiskComplement Membrane Attack Complexes Assemble NLRP3 Inflammasomes Triggering IL-1 Activation of IFN-γ–Primed Human EndotheliumLRP1 Deficiency in Vascular SMC Leads to Pulmonary Arterial Hypertension That Is Reversed by PPARγ Activationis related toImpaired Retinal Vessel Dilation Predicts Mortality in End-Stage Renal DiseaseNdufs2 Mediates Hypoxic Pulmonary Vasoconstriction (p 1727)Download figureDownload PowerPointDr Kimberly Dunham-Snary earned her BS in Applied Biomolecular Science from Lakehead University, a Master of Forensic Science from Penn State University, and a PhD in Pathology from The University of Alabama at Birmingham. She is currently a CIHR Postdoctoral Fellow in the laboratory of Dr Stephen Archer at Queen’s University in Kingston, Ontario. Her main research focus is mitochondrial biology—how genetic and structural changes to mitochondria alter cell function in both physiology and pathology. The “whodunit mystery” nature of scientific inquiry is the primary driving force of Kimberly’s interest in science. Her work on pulmonary vascular oxygen-sensing combines an investigation of a complex physiologic mechanism with yet another aspect of mitochondrial function and biology. Kimberly intends to establish her own research program, where she will be able make a lasting impact on future students in the many ways her mentors have shaped her. Outside the lab, Kimberly enjoys walking her dog, reading a good book (like Lamb by Christopher Moore), and watching a witty movie, especially The Grand Budapest Hotel. She shares an interest in motorsports (F1) and traveling with her husband; they live by the sound advice of Gord Downie: “There’s no dress rehearsal, this is our life.”MAC Induces Inflammasomes in Human Endothelium (p 1747)Download figureDownload PowerPointCatherine Xie is an MD/PhD student at Yale pursuing her graduate studies in Immunobiology in the laboratory of Dr Jordan Pober. Catherine earned her BS in Bioengineering and an English minor from the California Institute of Technology. As a first year undergraduate, she joined the lab of Dr Frances Arnold in protein engineering. Catherine developed a passion for human immunology and worked in the lab of Dr Garry Fathman at Stanford as a summer research fellow prior to joining the lab of Dr David Baltimore for two years, studying the role of microRNAs in leukemia pathogenesis. She was a Gates Cambridge Scholar at the University of Cambridge, where she earned an MPhil in Clinical Science (Translational Medicine and Therapeutics) and worked in the lab of Dr Morris Brown on gain-of-function mutations in the calcium channel, CaV1.3, found in aldosterone-producing adenomas. She is an aspiring physician-scientist and hopes to have her own lab focused on studying mechanisms underlying human immunological disease and translating findings into novel therapies and diagnostics. Catherine loves to explore the outdoors through hiking and running. She ran her first marathon last year and will be running the NYC marathon this fall. Her favorite books are Breathing Lessons, Guns Germs and Steel, and When Breathe Becomes Air. Her favorite motto is, “Stay Determined.”LRP1 Deficiency in VSMC Leads to PAH (p 1778)Download figureDownload PowerPointLaurent Calvier is working on the biology of biomarkers/biotargets involved in cardiovascular diseases. He has studied different diseases (such as systemic and pulmonary hypertension, heart and kidney failure, atherosclerosis or multiple sclerosis [MS]) in different organs, all related to vascular dysfunction. He started his research as a PhD student in the INSERM institute in Nancy, France. Under the supervision of Dr Natalia López-Andrés and Dr Patrick Rossignol, he conducted his research on the role of biomarkers in vascular remodeling during hypertension. During his postdoctoral training, he studied pulmonary vascular hypertension at Hannover Medical School (MHH, Germany), which provided a great opportunity to develop translational research under the supervision of Dr Georg Hansmann. For his second postdoctoral training, he is studying chronic inflammatory diseases related to leukocyte extravasation as atherosclerosis or MS. This project is conducted in the department of Molecular Genetics (UT Southwestern, Dallas, TX) directed by M. Brown, MD, and J. Goldstein, MD, Nobel Prizes on cholesterol metabolism and under the mentoring of Dr Joachim Herz, renowned for his discoveries on LDL receptors and ligands in neurodegeneration. His favorite movies are 2001: A Space Odyssey, The Hitchhiker’s Guide to the Galaxy, The Boat That Rocked, and Death at a Funeral, and his favorite motto is, “The harder I work, the luckier I get.”Propentdyopents and Cerebral Vascular Diameter (p e101)Download figureDownload PowerPointDr Alexander Joerk was born and raised in Gera town (Thuringia, Germany). He moved to Jena and completed his medical studies in 2015. During his MD thesis, graduating with summa cum laude, he studied the vasoactivity of heme degradation products on cerebral vasculature. Currently, Alexander is a postdoctoral fellow in the Department of Neurology, University Hospital of Jena, under the mentorship of Dr K. Holthoff and Dr O. Witte. His research focuses on investigating the pathogenesis and prevention of cerebral vasospasm after hemorrhagic strokes using genetic mouse models. Alexander plans to pursue a career as neurologist and aspire to become an expert in neurovascular biology. Outside the lab, he enjoys playing piano and organ music, writing poems and science fiction novels, and spending time as tourist guide in his hometown. His favorite motto (from Theodore Roosevelt) is, “Keep your eyes on the stars and your feet on the ground.”Microvascular Dysfunction and Mortality in ESRD (p 1796Download figureDownload PowerPointDr Roman Günthner is a nephrology resident and postdoctoral research scientist at the University Hospital of the Technical University of Munich in Dr Christoph Schmaderer’s laboratory. He earned his MD from Ludwig Maximilian University Munich in 2015 and completed his doctoral thesis in the lab of Dr Hans-Joachim Anders, investigating innate immunity and ischemia-reperfusion injury of the kidney. After joining the Department of Nephrology at Klinikum Rechts der Isar in Munich, he focused his research interest on measuring microcirculatory dysfunction using retinal vessel analysis. His future goal is to provide more insight into pathophysiological mechanisms of an altered microcirculation in nephrological, rheumatological, and cardiovascular diseases. In his spare time, he enjoys traveling the world, as well as hiking and skiing in the nearby Bavarian Alps. His life motto is, “Just do your best and don’t worry,” and his favorite movies include The Departed and Back to the Future.Microbial Association of Plasma Metabolome and CVD (p 1808Download figureDownload PowerPointDr Alexander Kurilshikov earned an MS and a PhD in genetics and molecular biology in Novosibirsk, Russia. He became a postdoctoral fellow in the Department of Genetics at the University Medical Centre Groningen, The Netherlands, in 2016. His main research focuses on host-environment-microbiome interplay and how it impacts human health and disease. His studies cover many aspects of this crosstalk, including the roles of the environment and human genetics in shaping gut microbiome structure and the subsequent contribution of gut microbes to a broad range of human diseases and disease-related phenotypes. Dr Kurilshikov believes that a better understanding of the gut microbiome will be translated into efficient diagnostic tools and treatment strategies for many non-communicable diseases. This is a cautious optimism, however, because, “Theory and practice sometimes clash. And when that happens, theory loses. Every single time.” (Linus Torvalds)Microbial Association of Plasma Metabolome and CVD (p 1808Download figureDownload PowerPointDr Inge van den Munckhof is a PhD student in the Department of Internal Medicine of the Radboud University Medical Center, Nijmegen, The Netherlands, under supervision of Drs de Graaf, Riksen, and Netea. As a member of the IN CONTROL consortium funded by the Dutch Heart Foundation, Inge focuses on the role of low-grade inflammation and the gut microbiota on cardiovascular disease. Inge became interested in the pathophysiology of atherosclerosis while earning a BS in Medicine, and her passion for this subject has only expanded since then. Working both as a medical doctor and PhD student has been challenging at times, but Inge remains determined to pursue a medical and scientific career because of her desire to improve human health. As a young mother, she enjoys family life with her partner and their lovely baby girl. Besides this, Inge loves to spend time with the rest of her family and her friends, but she also enjoys traveling and discovering new places. She loves being outside and going for walks with her white Shepherd. Her motto is, “pura vida (pure life)!” Previous Back to top Next FiguresReferencesRelatedDetailsRelated articlesNdufs2, a Core Subunit of Mitochondrial Complex I, Is Essential for Acute Oxygen-Sensing and Hypoxic Pulmonary VasoconstrictionKimberly J. Dunham-Snary, et al. Circulation Research. 2019;124:1727-1746Impaired Retinal Vessel Dilation Predicts Mortality in End-Stage Renal DiseaseRoman Günthner, et al. Circulation Research. 2019;124:1796-1807Propentdyopents as Heme Degradation Intermediates Constrict Mouse Cerebral Arterioles and Are Present in the Cerebrospinal Fluid of Patients With Subarachnoid HemorrhageAlexander Joerk, et al. Circulation Research. 2019;124:e101-e114Gut Microbial Associations to Plasma Metabolites Linked to Cardiovascular Phenotypes and RiskAlexander Kurilshikov, et al. Circulation Research. 2019;124:1808-1820Complement Membrane Attack Complexes Assemble NLRP3 Inflammasomes Triggering IL-1 Activation of IFN-γ–Primed Human EndotheliumCatherine B. Xie, et al. Circulation Research. 2019;124:1747-1759LRP1 Deficiency in Vascular SMC Leads to Pulmonary Arterial Hypertension That Is Reversed by PPARγ ActivationLaurent Calvier, et al. Circulation Research. 2019;124:1778-1785 June 7, 2019Vol 124, Issue 12 Advertisement Article InformationMetrics © 2019 American Heart Association, Inc.https://doi.org/10.1161/RES.0000000000000278PMID: 31170046 Originally publishedJune 6, 2019 PDF download Advertisement
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