Controlled release of biologically active compounds from bioerodible polymers
2006; Elsevier BV; Linguagem: Inglês
10.1016/b978-008045154-1/50001-0
Autores Tópico(s)Electrospun Nanofibers in Biomedical Applications
ResumoThis article reviews the controlled release of biologically active agents by the erosion or chemical degradation of a polymer matrix into which the agent is incorporated. Chemically bound active agents and work on steroid release from cholesterol implants are not covered. The mechanisms of polymer erosion discussed are: cross-linked scission; hydrolysis, ionization or protonation of pendant groupts; backbone cleavage. Drug release studies are dealt with under each of these headings.
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