Reversible Cell‐Specific Drug Delivery with Aptamer‐Functionalized Liposomes
2009; Wiley; Volume: 121; Issue: 35 Linguagem: Inglês
10.1002/ange.200901452
ISSN1521-3757
AutoresZehui Cao, Rong Tong, Abhijit Mishra, Weichen Xu, Gerard C. L. Wong, Jianjun Cheng, Yi Lu,
Tópico(s)Nanoparticle-Based Drug Delivery
ResumoAngewandte ChemieVolume 121, Issue 35 p. 6616-6620 Zuschrift Reversible Cell-Specific Drug Delivery with Aptamer-Functionalized Liposomes† Zehui Cao Dr., Zehui Cao Dr. Department of Chemistry, University of Illinois at Urbana-Champaign, 600 S. Mathews Avenue, Urbana, IL 61801 (USA), Fax: (+1) 217-244-3186 Z.C. and R.T. contributed equally to this work.Search for more papers by this authorRong Tong, Rong Tong Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, 1304 W. Green Street, Urbana, IL 61801 (USA), Fax: (+1) 217-333-2736 http://www.matse.illinois.edu/faculty/wong/profile.html http://www.matse.illinois.edu/faculty/cheng/profile.html Z.C. and R.T. contributed equally to this work.Search for more papers by this authorAbhijit Mishra, Abhijit Mishra Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, 1304 W. Green Street, Urbana, IL 61801 (USA), Fax: (+1) 217-333-2736 http://www.matse.illinois.edu/faculty/wong/profile.html http://www.matse.illinois.edu/faculty/cheng/profile.htmlSearch for more papers by this authorWeichen Xu, Weichen Xu Department of Chemistry, University of Illinois at Urbana-Champaign, 600 S. Mathews Avenue, Urbana, IL 61801 (USA), Fax: (+1) 217-244-3186Search for more papers by this authorGerard C. L. Wong Prof., Gerard C. L. Wong Prof. [email protected] Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, 1304 W. Green Street, Urbana, IL 61801 (USA), Fax: (+1) 217-333-2736 http://www.matse.illinois.edu/faculty/wong/profile.html http://www.matse.illinois.edu/faculty/cheng/profile.htmlSearch for more papers by this authorJianjun Cheng Prof., Jianjun Cheng Prof. [email protected] Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, 1304 W. Green Street, Urbana, IL 61801 (USA), Fax: (+1) 217-333-2736 http://www.matse.illinois.edu/faculty/wong/profile.html http://www.matse.illinois.edu/faculty/cheng/profile.htmlSearch for more papers by this authorYi Lu Prof., Yi Lu Prof. [email protected] Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, 1304 W. Green Street, Urbana, IL 61801 (USA), Fax: (+1) 217-333-2736 http://www.matse.illinois.edu/faculty/wong/profile.html http://www.matse.illinois.edu/faculty/cheng/profile.html Department of Chemistry, University of Illinois at Urbana-Champaign, 600 S. Mathews Avenue, Urbana, IL 61801 (USA), Fax: (+1) 217-244-3186Search for more papers by this author Zehui Cao Dr., Zehui Cao Dr. Department of Chemistry, University of Illinois at Urbana-Champaign, 600 S. Mathews Avenue, Urbana, IL 61801 (USA), Fax: (+1) 217-244-3186 Z.C. and R.T. contributed equally to this work.Search for more papers by this authorRong Tong, Rong Tong Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, 1304 W. Green Street, Urbana, IL 61801 (USA), Fax: (+1) 217-333-2736 http://www.matse.illinois.edu/faculty/wong/profile.html http://www.matse.illinois.edu/faculty/cheng/profile.html Z.C. and R.T. contributed equally to this work.Search for more papers by this authorAbhijit Mishra, Abhijit Mishra Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, 1304 W. Green Street, Urbana, IL 61801 (USA), Fax: (+1) 217-333-2736 http://www.matse.illinois.edu/faculty/wong/profile.html http://www.matse.illinois.edu/faculty/cheng/profile.htmlSearch for more papers by this authorWeichen Xu, Weichen Xu Department of Chemistry, University of Illinois at Urbana-Champaign, 600 S. Mathews Avenue, Urbana, IL 61801 (USA), Fax: (+1) 217-244-3186Search for more papers by this authorGerard C. L. Wong Prof., Gerard C. L. Wong Prof. [email protected] Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, 1304 W. Green Street, Urbana, IL 61801 (USA), Fax: (+1) 217-333-2736 http://www.matse.illinois.edu/faculty/wong/profile.html http://www.matse.illinois.edu/faculty/cheng/profile.htmlSearch for more papers by this authorJianjun Cheng Prof., Jianjun Cheng Prof. [email protected] Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, 1304 W. Green Street, Urbana, IL 61801 (USA), Fax: (+1) 217-333-2736 http://www.matse.illinois.edu/faculty/wong/profile.html http://www.matse.illinois.edu/faculty/cheng/profile.htmlSearch for more papers by this authorYi Lu Prof., Yi Lu Prof. [email protected] Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, 1304 W. Green Street, Urbana, IL 61801 (USA), Fax: (+1) 217-333-2736 http://www.matse.illinois.edu/faculty/wong/profile.html http://www.matse.illinois.edu/faculty/cheng/profile.html Department of Chemistry, University of Illinois at Urbana-Champaign, 600 S. Mathews Avenue, Urbana, IL 61801 (USA), Fax: (+1) 217-244-3186Search for more papers by this author First published: 12 August 2009 https://doi.org/10.1002/ange.200901452Citations: 36 † This work was supported by a National Science Foundation Nanoscale Science and Engineering Center grant (DMR-0117792). J.C. thanks support from the National Science Foundation Career Program (DMR-0748834) and the Siteman Center for Cancer Nanotechnology Excellence (SCCNE, Washington University)—Center for Nanoscale Science and Technology (CNST, UIUC). Read the full textAboutPDF ToolsRequest permissionAdd to favorites ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Graphical Abstract Vorteil Aptamer: Eine zellspezifische Freisetzung des Tumortherapeutikums Cisplatin mithilfe eines Nucleolin-Aptamer-konjugierten, Cisplatin-verkapselnden Liposomsystems wird vorgestellt. Calcein wurde in die MCF-7-Zielzellen eingeschlossen (oberes Bild), nicht jedoch in LNCaP-Zellen (unteres Bild). Wesentlich ist zudem, dass das Ausmaß der Freisetzung mit einer zum Aptamer komplementären DNA als Antidot eingestellt werden kann. 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