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Therapeutic Efficacy Of Extended Release Oxybutynin Chloride, And Immediate Release And Long Acting Tolterodine Tartrate In Children With Diurnal Urinary Incontinence

2003; Lippincott Williams & Wilkins; Volume: 169; Issue: 1 Linguagem: Inglês

10.1016/s0022-5347(05)64115-8

1527-3792

Yuri Reinberg, Jennifer Crocker, James J. Wolpert, David R. Vandersteen,

Urinary Tract Infections Management

No AccessJournal of UrologyPEDIATRIC UROLOGY1 Jan 2003Therapeutic Efficacy Of Extended Release Oxybutynin Chloride, And Immediate Release And Long Acting Tolterodine Tartrate In Children With Diurnal Urinary Incontinence Y. REINBERG, J. CROCKER, J. WOLPERT, and D. VANDERSTEEN Y. REINBERGY. REINBERG , J. CROCKERJ. CROCKER , J. WOLPERTJ. WOLPERT , and D. VANDERSTEEND. VANDERSTEEN View All Author Informationhttps://doi.org/10.1016/S0022-5347(05)64115-8AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We compare the tolerability and efficacy of extended release oxybutynin chloride, and immediate release and long acting tolterodine tartrate in children with nonneurogenic diurnal urinary incontinence and symptoms of overactive bladder. Materials and Methods: Children with a history of diurnal urinary incontinence were arbitrarily assigned to extended release oxybutynin, immediate release tolterodine or long acting tolterodine. The dose was titrated until effective (onset of complete diurnal urinary continence), maximal recommended dosage was achieved or bothersome anticholinergic side effects developed. An independent observer recorded the dose used, anticholingeric side effects and efficacy of therapy (incidence of urinary frequency, urgency, posturing and urinary incontinence). Results: The study included 86 girls and 46 boys. There were no statistically significant differences among the 3 treatment groups regarding the presence of peripheral or central nervous system anticholinergic side effects. Extended release oxybutynin and long acting tolterodine were significantly more effective at reducing daytime urinary incontinence than immediate release tolterodine (p <0.01 and 0 <0.05, respectively). Extended release oxybutynin was significantly more effective then long acting tolterodine for complete resolution of diurnal incontinence (p <0.05). Conclusions: Extended release oxybutynin and long acting tolterodine are more effective than immediate release tolterodine in decreasing diurnal urinary incontinence. Extended release oxybutynin chloride is more effective than either immediate or long acting tolterodine for control of daytime urinary incontinence and urinary frequency. References 1 : Micturition habits and incontinence in 7-year-old Swedish school entrants. Eur J Pediatr1990; 149: 434. Google Scholar 2 : Hinman syndrome: a vicious cycle. Urology1993; 42: 317. Google Scholar 3 : The overactive bladder in childhood: long-term results with conservative management. J Urol2000; 163: 574. Link, Google Scholar 4 : Behavioral and self-concept changes after six months of enuresis treatment: a randomized, controlled trial. Pediatrics2000; 105: 935. Google Scholar 5 : Enuresis. 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Google Scholar From The Center for Pediatric Urology, Pediatric Surgical Associates, Minneapolis, Minnesota© 2003 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited ByQuintiliano F, Veiga M, Moraes M, Cunha C, de Oliveira L, Lordelo P, Bastos Netto J and Barroso Júnior U (2015) Transcutaneous Parasacral Electrical Stimulation vs Oxybutynin for the Treatment of Overactive Bladder in Children: A Randomized Clinical TrialJournal of Urology, VOL. 193, NO. 5S, (1749-1753), Online publication date: 1-May-2015.De Gennaro M, Capitanucci M, Mosiello G and Zaccara A (2018) Current State of Nerve Stimulation Technique for Lower Urinary Tract Dysfunction in ChildrenJournal of Urology, VOL. 185, NO. 5, (1571-1577), Online publication date: 1-May-2011.Bolduc S, Moore K, Nadeau G, Lebel S, Lamontagne P and Hamel M (2010) Prospective Open Label Study of Solifenacin for Overactive Bladder in ChildrenJournal of Urology, VOL. 184, NO. 4S, (1668-1673), Online publication date: 1-Oct-2010.Hagstroem S, Rittig S, Kamperis K and Djurhuus J (2018) Timer Watch Assisted Urotherapy in Children: A Randomized Controlled TrialJournal of Urology, VOL. 184, NO. 4, (1482-1488), Online publication date: 1-Oct-2010.NIJMAN R, BORGSTEIN N, ELLSWORTH P and DJURHUUS J (2018) TOLTERODINE TREATMENT FOR CHILDREN WITH SYMPTOMS OF URINARY URGE INCONTINENCE SUGGESTIVE OF DETRUSOR OVERACTIVITY: RESULTS FROM 2 RANDOMIZED, PLACEBO CONTROLLED TRIALSJournal of Urology, VOL. 173, NO. 4, (1334-1339), Online publication date: 1-Apr-2005.MARSCHALL-KEHREL A, MÜRTZ G, KRAMER G, JÜNEMANN K and MADERSBACHER H (2018) AN EMPIRICAL TREATMENT ALGORITHM FOR INCONTINENT CHILDRENJournal of Urology, VOL. 171, NO. 6 Part 2, (2667-2671), Online publication date: 1-Jun-2004. Volume 169Issue 1January 2003Page: 317-319 Advertisement Copyright & Permissions© 2003 by American Urological Association, Inc.Keywordsdrug therapypediatricsenuresisurinary incontinenceMetricsAuthor Information Y. REINBERG Requests for reprints: Pediatric Surgical Associates, 2545 Chicago Avenue South, Number 104, Minneapolis, Minnesota 55404. Financial interest and/or other relationship with Alza and Pharmacia. More articles by this author J. CROCKER More articles by this author J. WOLPERT More articles by this author D. VANDERSTEEN More articles by this author Expand All Advertisement PDF DownloadLoading ...