Clotrimazole
1982; Elsevier BV; Linguagem: Inglês
10.1016/s0099-5428(08)60265-8
ISSN2163-5846
AutoresJohn G. Hoogerheide, Bruce Wyka,
Tópico(s)Essential Oils and Antimicrobial Activity
ResumoThis chapter provides an overview of clotrimazole. It discusses the names, formula, molecular weight, and structure, drug properties, and appearance, color, odor, and taste of clotrimazole. Various physical properties—nuclear magnetic resonance spectra, mass spectrum, infrared spectrum, ultraviolet spectrum, melting range, thermal properties, crystal properties, solubility, and dissociation constant—are discussed. The chapter reviews the synthesis of clotrimazole, and discusses the drug metabolism and pharmacokinetics. Clotrimazole is a colorless, odorless, tasteless, crystalline solid. Preparations of the drug are used both in the topical treatment of dermal infections and to combat vulvovaginal candidiasis. Clotrimazole is stable in the solid state under normal storage conditions. It is unaffected by heat (70˚C) and exposure to daylight for up to two weeks. Various methods of analysis of clotrimazole are discussed—elemental analysis, identification, spectrophotometric analysis, titrimetric analysis, chromatographic analysis, radiochemical analysis, microcalorimetric analysis, and microbiological analysis.
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