Portal de Periódicos da CAPES

Acrokeratoelastoidosis

2005; Wiley; Volume: 44; Issue: 5 Linguagem: Inglês

10.1111/j.1365-4632.2005.01980.x

1365-4632

Salina Tsai, Nicole P. Kageyama, Mandy L. Warthan, Clay J. Cockerell,

Wnt/β-catenin signaling in development and cancer

A 45‐year‐old white woman presented with several years’ history of firm, shiny papules on the lateral hands with slight extension to the dorsal fingers. The lesions first appeared between the index fingers and thumbs on both hands. They gradually increased in number, coalescing into plaques and affecting the junction between the palmar and dorsal skin. The patient did not have involvement of her feet. She had been diagnosed previously with chronic eczema that had failed to respond to multiple topical medications. In addition, the patient's sister had similar lesions on both hands. The patient denied any symptoms of hyperhidrosis, excessive sun exposure, or trauma. The plaques were asymptomatic, but were cosmetically unappealing to the patient. On physical examination, small, firm, skin‐colored, hyperkeratotic papules, coalescing into plaques, were located on the junction between the palmar and dorsal skin on both lateral margins of the thumb and on the radial side of the index finger ( Fig. 1 ). There were no lesions on the feet. Small, firm, skin‐colored, hyperkeratotic papules, coalescing into plaques, seen on the right medial hand show the characteristic changes of acrokeratoelastoidosis image A biopsy taken from a papule on the patient's left hand was consistent histologically with acrokeratoelastoidosis. The biopsy showed marked degeneration of collagen in the dermis with solar elastosis and some smudging of the papillary dermal collagen ( Fig. 2 ). Hematoxylin and eosin stain from a biopsy of the right medial hand shows marked degeneration of collagen in the dermis with solar elastosis and some smudging of the papillary dermal collagen (× 4) image She was treated with clobetasone cream to the affected areas on the hands. After 6 weeks of treatment, she reported no significant improvement.