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Snapshots of the Reaction Mechanism of Matrix Metalloproteinases

2006; Wiley; Volume: 118; Issue: 47 Linguagem: Inglês

10.1002/ange.200603100

1521-3757

Ivano Bertini, V. Calderone, Marco Fragai, Claudio Luchinat, M. Maletta, Kwon Joo Yeo,

Enzyme Production and Characterization

Angewandte ChemieVolume 118, Issue 47 p. 8120-8123 Zuschrift Snapshots of the Reaction Mechanism of Matrix Metalloproteinases† Ivano Bertini Prof., Ivano Bertini Prof. ivanobertini@cerm.unifi.it Magnetic Resonance Center (CERM), University of Florence, Via L. Sacconi 6, 50019 Sesto Fiorentino, Italy, Fax: (+39) 055-457-4271 Department of Chemistry, University of Florence, Via della Lastruccia 3, 50019 Sesto Fiorentino, ItalySearch for more papers by this authorVito Calderone, Vito Calderone Magnetic Resonance Center (CERM), University of Florence, Via L. Sacconi 6, 50019 Sesto Fiorentino, Italy, Fax: (+39) 055-457-4271Search for more papers by this authorMarco Fragai, Marco Fragai Magnetic Resonance Center (CERM), University of Florence, Via L. Sacconi 6, 50019 Sesto Fiorentino, Italy, Fax: (+39) 055-457-4271 Department of Agricultural Biotechnology, University of Florence, Via Maragliano 75–77, 50144 Florence, ItalySearch for more papers by this authorClaudio Luchinat, Claudio Luchinat Magnetic Resonance Center (CERM), University of Florence, Via L. Sacconi 6, 50019 Sesto Fiorentino, Italy, Fax: (+39) 055-457-4271 Department of Agricultural Biotechnology, University of Florence, Via Maragliano 75–77, 50144 Florence, ItalySearch for more papers by this authorMassimiliano Maletta, Massimiliano Maletta Magnetic Resonance Center (CERM), University of Florence, Via L. Sacconi 6, 50019 Sesto Fiorentino, Italy, Fax: (+39) 055-457-4271 Department of Chemistry, University of Florence, Via della Lastruccia 3, 50019 Sesto Fiorentino, ItalySearch for more papers by this authorKwon Joo Yeo, Kwon Joo Yeo Magnetic Resonance Center (CERM), University of Florence, Via L. Sacconi 6, 50019 Sesto Fiorentino, Italy, Fax: (+39) 055-457-4271Search for more papers by this author Ivano Bertini Prof., Ivano Bertini Prof. ivanobertini@cerm.unifi.it Magnetic Resonance Center (CERM), University of Florence, Via L. Sacconi 6, 50019 Sesto Fiorentino, Italy, Fax: (+39) 055-457-4271 Department of Chemistry, University of Florence, Via della Lastruccia 3, 50019 Sesto Fiorentino, ItalySearch for more papers by this authorVito Calderone, Vito Calderone Magnetic Resonance Center (CERM), University of Florence, Via L. Sacconi 6, 50019 Sesto Fiorentino, Italy, Fax: (+39) 055-457-4271Search for more papers by this authorMarco Fragai, Marco Fragai Magnetic Resonance Center (CERM), University of Florence, Via L. Sacconi 6, 50019 Sesto Fiorentino, Italy, Fax: (+39) 055-457-4271 Department of Agricultural Biotechnology, University of Florence, Via Maragliano 75–77, 50144 Florence, ItalySearch for more papers by this authorClaudio Luchinat, Claudio Luchinat Magnetic Resonance Center (CERM), University of Florence, Via L. Sacconi 6, 50019 Sesto Fiorentino, Italy, Fax: (+39) 055-457-4271 Department of Agricultural Biotechnology, University of Florence, Via Maragliano 75–77, 50144 Florence, ItalySearch for more papers by this authorMassimiliano Maletta, Massimiliano Maletta Magnetic Resonance Center (CERM), University of Florence, Via L. Sacconi 6, 50019 Sesto Fiorentino, Italy, Fax: (+39) 055-457-4271 Department of Chemistry, University of Florence, Via della Lastruccia 3, 50019 Sesto Fiorentino, ItalySearch for more papers by this authorKwon Joo Yeo, Kwon Joo Yeo Magnetic Resonance Center (CERM), University of Florence, Via L. Sacconi 6, 50019 Sesto Fiorentino, Italy, Fax: (+39) 055-457-4271Search for more papers by this author First published: 27 November 2006 https://doi.org/10.1002/ange.200603100Citations: 7 † We thank Dr. Andrea Giachetti for help with computational analysis. This research was supported by the EC (projects: LSHG-CT-2004-512077 and "Structural Proteomics in Europe" Grant QLG2-CT-2002-00988), the MIUR (PRIN 2005, Prot. N. 2005039878, Prot. N. 4455, and RBAU013NSB), and Ente Cassa di Risparmio di Firenze (Innovative Strategies for Drug Design). We acknowledge the support and assistance of the ESRF (Grenoble) and DESY (Hamburg) synchrotron radiation facilities for the data collection. Read the full textAboutPDF ToolsRequest permissionAdd to favorites ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Die Abfolge von Ereignissen, die im Katalysezyklus von Matrix-Metalloproteinasen eintreten, wurde auf der Basis von Kristallstrukturen der aktiven, nicht inhibierten Enzyme und derselben Enzyme nach Hydrolyse eines Peptidsubstrats modelliert. Nach dem Bruch der Peptidbindung bleiben beide Peptidfragmente zunächst an das Protein gebunden (siehe Struktur der Kavität am aktiven Zentrum des Enzyms MMP-12 direkt nach der Substrathydrolyse). Citing Literature Supporting Information Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2001/2006/z603100_s.html or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume118, Issue47December 4, 2006Pages 8120-8123 This is the German version of Angewandte Chemie. Note for articles published since 1962: Do not cite this version alone. Take me to the International Edition version with citable page numbers, DOI, and citation export. We apologize for the inconvenience. RelatedInformation