Portal de Periódicos da CAPES

Membrane fusion

2002; Elsevier BV; Volume: 14; Issue: 4 Linguagem: Inglês

10.1016/s0955-0674(02)00356-3

1879-0410

Reinhard Jahn, Helmut Grubmüller,

RNA and protein synthesis mechanisms

Fusion of biological membranes is governed by physical principles but it is unclear whether the transition states are primarily determined by lipid physics or by protein-lipid interactions. Recent advances in the field include the physical description of bilayer fusion, particularly new models beyond continuum models and the role of the SNARE proteins. Despite substantial progress, an integrated concept for protein-mediated membrane fusion is not yet available, and many open questions remain to be answered.