Portal de Periódicos da CAPES

Oral Communications

2014; De Gruyter; Volume: 52; Issue: Supplement Linguagem: Inglês

10.1515/cclm-2014-4002

1437-4331

Franca Cocci, Angela Papa, Melania Gaggini, M Schlüter, Massimiliano Bianchi, Chiara Caselli, Debora Battaglia, A. Mazzarisi, M.A. Morales, Amalia Gastaldelli, Paolo Marraccini, Katarzyna Fischer, Anna Walecka, Magdalena Ostanek, Marcin Sawicki, Agnieszka Bińczak‐Kuleta, Lidia Ostanek, Andrzej Ciechanowicz, Iwona Brzosko, Marek Brzosko, K. Großmann, Nadja Röber, Rico Hiemann, Mathew E. Sowa, Ilka Knütter, Dirk Reinhold, Martin W. Laaß, Karsten Conrad, Dirk Roggenbuck, Juliane Scholz, Peter Schierack, Giovanni Luca Scaglione, Donatella Guarino, Paola Concolino, Cristina Santonocito, Flavio Mignone, Igor Saggese, Alessandra Costella, Angelo Minucci, Ettore Capoluongo, L Klinkenberg, Jan van Dijk,

Oral Health Pathology and Treatment

BACKGROUND: CT coronary angiography (CTCA) is increasingly used for the diagnosis of CAD.The identification of appropriate biomarkers may allow a better evaluation of the pre-test probability of CAD.Osteoprotegerin (OPG), a glycoprotein associated with diabetic disease, prevalence and severity of CAD, may be considered a potential candidate for cardiovascular risk stratification.The involvement of OPG in CAD has been already described; however the usefulness of OPG as a biomarker needs to be further investigated.Aim of this study was to evaluate the role of serum OPG levels for the stratification of patients undergoing CTCA.METHODS: we enrolled 190 consecutive patients (age 62.2 ± 12.0 yrs, 63% men) undergoing CTCA for chest pain screening.Blood samples were drawn before the CTCA procedure for OPG (Instant ELISA, Bender MedSystems) determination.HOMA index, Framingham risk score and the SCORE (10-year risk of fatal cardiovascular disease) were also calculated in all patients.Log-transformed OPG values were used for all statistical analysis. RESULTS:Mean ln(OPG) levels were 4.28 ± 0.72 pg/ml for all subjects.ln(OPG) concentrations were significantly higher in patients with atherosclerosis than in those without disease (4.34 ± 0.06 vs 4.10 ± 0.09 pg/ml; p=0.028).Moreover ln(OPG) was able to discriminate patients according to the presence or not of a >50 % coronary stenosis (4.48 ± 0.08 vs 4.17 ± 0.09; p=0.003) and to the extension of the coronary atherosclerosis (1-2-3 vessels) (4.34 ± 0.12, 4.50 ± 0.16, 4.65 ± 0.14, respectively; p=0.0005).ln(OPG) levels were positively correlated with Framingham (p=0.008),SCORE (p=0.006) and the HOMA index (p=0.04).CONCLUSIONS: in the cardiovascular risk assessment serum OPG determination may improve stratification of patients candidate to further imaging investigations.