Structural features and biological activities of the cathelicidin‐derived antimicrobial peptides
2000; Wiley; Volume: 55; Issue: 1 Linguagem: Inglês
10.1002/1097-0282(2000)55
ISSN1097-0282
AutoresRenato Gennaro, Margherita Zanetti,
Tópico(s)Probiotics and Fermented Foods
ResumoPeptide ScienceVolume 55, Issue 1 p. 31-49 Structural features and biological activities of the cathelicidin-derived antimicrobial peptides Renato Gennaro, Corresponding Author Renato Gennaro [email protected] Dipartimento di Biochimica, Biofisica e Chimica delle Macromolecole, Università di Trieste, Via Giorgieri, 1, 34127 Trieste, ItalyDipartimento di Biochimica, Biofisica e Chimica delle Macromolecole, Università di Trieste, Via Giorgieri, 1, 34127 Trieste, Italy===Search for more papers by this authorMargherita Zanetti, Margherita Zanetti Dipartimento di Scienze e Tecnologie Biomediche, Università di Udine, P.le Kolbe, 4, 33100 Udine, Italy Laboratorio Nazionale CIB, AREA Science Park, 34012 Padriciano-Trieste, ItalySearch for more papers by this author Renato Gennaro, Corresponding Author Renato Gennaro [email protected] Dipartimento di Biochimica, Biofisica e Chimica delle Macromolecole, Università di Trieste, Via Giorgieri, 1, 34127 Trieste, ItalyDipartimento di Biochimica, Biofisica e Chimica delle Macromolecole, Università di Trieste, Via Giorgieri, 1, 34127 Trieste, Italy===Search for more papers by this authorMargherita Zanetti, Margherita Zanetti Dipartimento di Scienze e Tecnologie Biomediche, Università di Udine, P.le Kolbe, 4, 33100 Udine, Italy Laboratorio Nazionale CIB, AREA Science Park, 34012 Padriciano-Trieste, ItalySearch for more papers by this author First published: 12 January 2004 https://doi.org/10.1002/1097-0282(2000)55:1 3.0.CO;2-9Citations: 231Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Abstract Cathelicidins are a numerous group of mammalian proteins that carry diverse antimicrobial peptides at the C-terminus of a highly conserved preproregion. These peptides, which become active when released from the proregion, display a remarkable variety of sizes, sequences, and structures, and in fact comprise representatives of all the structural groups in which the known antimicrobial peptides have been classified. Most of the cathelicidin-derived peptides exert a broad spectrum and potent antimicrobial activity and also bind to lipopolysaccharide and neutralize its effects. In addition, some of them have recently been shown to exert other activities and might participate in host defense also by virtue of their ability to induce expression of molecules involved in a variety of biological processes. This review is aimed at providing a general overview of the cathelicidins and of the peptides derived therefrom, with emphasis on aspects such as structure, biological activities in vitro and in vivo, and structure/activity relationship studies. © 2000 John Wiley & Sons, Inc. Biopoly 55: 31–49, 2000 REFERENCES 1 Lehrer, R. I.; Lichtenstein, A. K.; Ganz, T. Ann Rev Immunol 1993, 11, 105–128. 10.1146/annurev.iy.11.040193.000541 CASPubMedWeb of Science®Google Scholar 2 Ganz, T.; Lehrer, R. I. Pharmac Ther 1995, 66, 191–205. 10.1016/0163-7258(94)00076-F CASPubMedWeb of Science®Google Scholar 3 Selsted, M. E.; Ouellette, A. J. Trends Cell Biol 1995, 5, 114–119. 10.1016/S0962-8924(00)88961-8 CASPubMedWeb of Science®Google Scholar 4 Ouellette, A. J.; Selsted, M. E. FASEB J 1996, 10, 1280–1289. 10.1096/fasebj.10.11.8836041 CASPubMedWeb of Science®Google Scholar 5 Ganz, T.; Lehrer, R. I. 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