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Evaluation of Urinary Carnitine and Taurine Excretion in 5 Cystinuric Dogs with Carnitine and Taurine Deficiency

2001; Wiley; Volume: 15; Issue: 2 Linguagem: Inglês

10.1892/0891-6640(2001)015 2.3.co;2

1939-1676

S. Laurie Sanderson, Carl A. Osborne, Jody P. Lulich, Joseph W. Bartges, Mary Ella Pierpont, Phillip N. Ogburn, Lori A. Koehler, Laurie L. Swanson, Kathy A. Bird, Lisa K. Ulrich,

Prenatal Substance Exposure Effects

Journal of Veterinary Internal MedicineVolume 15, Issue 2 p. 94-100 Open Access Evaluation of Urinary Carnitine and Taurine Excretion in 5 Cystinuric Dogs with Carnitine and Taurine Deficiency Sherry L. Sanderson, Corresponding Author Sherry L. Sanderson Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul, MN Department of Small Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens, GA 30602; e-mail: sanderso@calc.vet.uga.edu.Search for more papers by this authorCarl A. Osborne, Carl A. Osborne Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul, MNSearch for more papers by this authorJody P. Lulich, Jody P. Lulich Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul, MNSearch for more papers by this authorJoseph W. Bartges, Joseph W. Bartges Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul, MNSearch for more papers by this authorMary Ella Pierpont, Mary Ella Pierpont Department of Pediatrics, College of Medicine, University ofMinnesota, Minneapolis, MNSearch for more papers by this authorPhillip N. Ogburn, Phillip N. Ogburn Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul, MNSearch for more papers by this authorLori A. Koehler, Lori A. Koehler Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul, MNSearch for more papers by this authorLaurie L. Swanson, Laurie L. Swanson Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul, MNSearch for more papers by this authorKathy A. Bird, Kathy A. Bird Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul, MNSearch for more papers by this authorLisa K. Ulrich, Lisa K. Ulrich Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul, MNSearch for more papers by this author Sherry L. Sanderson, Corresponding Author Sherry L. Sanderson Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul, MN Department of Small Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens, GA 30602; e-mail: sanderso@calc.vet.uga.edu.Search for more papers by this authorCarl A. Osborne, Carl A. Osborne Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul, MNSearch for more papers by this authorJody P. Lulich, Jody P. Lulich Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul, MNSearch for more papers by this authorJoseph W. Bartges, Joseph W. Bartges Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul, MNSearch for more papers by this authorMary Ella Pierpont, Mary Ella Pierpont Department of Pediatrics, College of Medicine, University ofMinnesota, Minneapolis, MNSearch for more papers by this authorPhillip N. Ogburn, Phillip N. Ogburn Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul, MNSearch for more papers by this authorLori A. Koehler, Lori A. Koehler Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul, MNSearch for more papers by this authorLaurie L. Swanson, Laurie L. Swanson Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul, MNSearch for more papers by this authorKathy A. Bird, Kathy A. Bird Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul, MNSearch for more papers by this authorLisa K. Ulrich, Lisa K. Ulrich Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul, MNSearch for more papers by this author First published: 28 June 2008 https://doi.org/10.1111/j.1939-1676.2001.tb01238.xCitations: 21 Dr Bartges is presently affiliated with the Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, TN. AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Abstract Five client-owned dogs with cystinuria were diagnosed with carnitine and taurine deficiency while participating in a clinical trial that used dietary management of their urolithiasis. Stored 24-hour urine samples collected from the cystinuric dogs before enrollment in the clinical diet trial were quantitatively evaluated for carnitine and taurine. These results were compared to those obtained from 18 healthy Beagles. Both groups of dogs were fed the same maintenance diet for a minimum of 2 weeks before 24-hour urine collection. The protocol used for 24-hour urine collections was the same for cystinuric dogs and healthy Beagles except that cystinuric dogs were catheterized at baseline, 8 hours, 12 hours, and at the end of the collection, whereas Beagles were catheterized at baseline, 8 hours, and at the end of the collection. Three of 5 dogs with cystinuria had increased renal excretion of carnitine. None of the cystinuric dogs had increased renal excretion of taurine, but cystinuric dogs excreted significantly less (P < .05) taurine in their urine than the healthy Beagles. Carnitinuria has not been recognized previously in either humans or dogs with cystinuria, and it may be 1 risk factor for developing carnitine deficiency. Cystinuric dogs in this study were not taurinuric; however, cystine is a precursor amino acid for taurine synthesis. 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