Towards nucleopeptides containing any trifunctional amino acid
1999; Elsevier BV; Volume: 55; Issue: 46 Linguagem: Inglês
10.1016/s0040-4020(99)00815-7
ISSN1464-5416
AutoresJordi Robles, Maite Beltrán, Vicente Marchán, Yolanda Pérez, Isaura Travesset, Enrique Pedroso, Anna Grandas,
Tópico(s)RNA Interference and Gene Delivery
ResumoNucleopeptides incorporating, besides the linking residue, other trifunctional amino acids such as lysine, arginine, tryptophan, serine, threonine and tyrosine have been obtained following stepwise solid-phase assembly. The best alternatives for the protection of the side chains of these trifunctional amino acids are discussed. The use of different solid supports (polystyrene-co-1%-divinylbenzene, controlled pore glass and polyethylene glycol-polystyrene) and nucleopeptide-resin linkers has also been evaluated.
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