Portal de Periódicos da CAPES

Differentially Charged Hollow Core/Shell Lipid–Polymer–Lipid Hybrid Nanoparticles for Small Interfering RNA Delivery

2011; Wiley; Volume: 123; Issue: 31 Linguagem: Inglês

10.1002/ange.201101554

1521-3757

Jinjun Shi, Zeyu Xiao, Alexander R. Votruba, Cristián Vilos, Omid C. Farokhzad,

DNA and Nucleic Acid Chemistry

Angewandte ChemieVolume 123, Issue 31 p. 7165-7169 Zuschrift Differentially Charged Hollow Core/Shell Lipid–Polymer–Lipid Hybrid Nanoparticles for Small Interfering RNA Delivery† Dr. Jinjun Shi, Dr. Jinjun Shi Laboratory of Nanomedicine and Biomaterials, Department of Anesthesiology, Brigham and Women's Hospital, Boston, MA 02115 (USA), Fax: (+1) 617-730-2801 MIT–Harvard Center for Cancer Nanotechnology Excellence, Massachusetts Institute of Technology, Cambridge, MA 02139 (USA)Search for more papers by this authorDr. Zeyu Xiao, Dr. Zeyu Xiao Laboratory of Nanomedicine and Biomaterials, Department of Anesthesiology, Brigham and Women's Hospital, Boston, MA 02115 (USA), Fax: (+1) 617-730-2801 MIT–Harvard Center for Cancer Nanotechnology Excellence, Massachusetts Institute of Technology, Cambridge, MA 02139 (USA)Search for more papers by this authorAlexander R. Votruba, Alexander R. Votruba Laboratory of Nanomedicine and Biomaterials, Department of Anesthesiology, Brigham and Women's Hospital, Boston, MA 02115 (USA), Fax: (+1) 617-730-2801Search for more papers by this authorDr. Cristian Vilos, Dr. Cristian Vilos Laboratory of Nanomedicine and Biomaterials, Department of Anesthesiology, Brigham and Women's Hospital, Boston, MA 02115 (USA), Fax: (+1) 617-730-2801Search for more papers by this authorProf. Omid C. Farokhzad, Corresponding Author Prof. Omid C. Farokhzad ofarokhzad@zeus.bwh.harvard.edu Laboratory of Nanomedicine and Biomaterials, Department of Anesthesiology, Brigham and Women's Hospital, Boston, MA 02115 (USA), Fax: (+1) 617-730-2801 MIT–Harvard Center for Cancer Nanotechnology Excellence, Massachusetts Institute of Technology, Cambridge, MA 02139 (USA)Laboratory of Nanomedicine and Biomaterials, Department of Anesthesiology, Brigham and Women's Hospital, Boston, MA 02115 (USA), Fax: (+1) 617-730-2801Search for more papers by this author Dr. Jinjun Shi, Dr. Jinjun Shi Laboratory of Nanomedicine and Biomaterials, Department of Anesthesiology, Brigham and Women's Hospital, Boston, MA 02115 (USA), Fax: (+1) 617-730-2801 MIT–Harvard Center for Cancer Nanotechnology Excellence, Massachusetts Institute of Technology, Cambridge, MA 02139 (USA)Search for more papers by this authorDr. Zeyu Xiao, Dr. Zeyu Xiao Laboratory of Nanomedicine and Biomaterials, Department of Anesthesiology, Brigham and Women's Hospital, Boston, MA 02115 (USA), Fax: (+1) 617-730-2801 MIT–Harvard Center for Cancer Nanotechnology Excellence, Massachusetts Institute of Technology, Cambridge, MA 02139 (USA)Search for more papers by this authorAlexander R. Votruba, Alexander R. Votruba Laboratory of Nanomedicine and Biomaterials, Department of Anesthesiology, Brigham and Women's Hospital, Boston, MA 02115 (USA), Fax: (+1) 617-730-2801Search for more papers by this authorDr. Cristian Vilos, Dr. Cristian Vilos Laboratory of Nanomedicine and Biomaterials, Department of Anesthesiology, Brigham and Women's Hospital, Boston, MA 02115 (USA), Fax: (+1) 617-730-2801Search for more papers by this authorProf. Omid C. Farokhzad, Corresponding Author Prof. Omid C. Farokhzad ofarokhzad@zeus.bwh.harvard.edu Laboratory of Nanomedicine and Biomaterials, Department of Anesthesiology, Brigham and Women's Hospital, Boston, MA 02115 (USA), Fax: (+1) 617-730-2801 MIT–Harvard Center for Cancer Nanotechnology Excellence, Massachusetts Institute of Technology, Cambridge, MA 02139 (USA)Laboratory of Nanomedicine and Biomaterials, Department of Anesthesiology, Brigham and Women's Hospital, Boston, MA 02115 (USA), Fax: (+1) 617-730-2801Search for more papers by this author First published: 22 June 2011 https://doi.org/10.1002/ange.201101554Citations: 31 † This work was supported by National Institutes of Health (NIH) grants CA151884, EB003647, and N01 HV-08236, and the David Koch—Prostate Cancer Foundation Award in Nanotherapeutics. We also thank Dr. Akin Akinc (Alnylam Pharmaceuticals, Inc.) and Prof. Daniel G. Anderson (MIT) for providing Dual–Luc HeLa cells and GFP–HeLa cells. Read the full textAboutPDF ToolsRequest permissionAdd to favorites ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Graphical Abstract Schnellzustellung: Biologisch abbaubare und verträgliche Polymere und Lipide bilden Kern-Schale-Hybridnanopartikel (links im Bild) für den Transport von siRNA in vitro wie in vivo. Die einzigartige Lipid-Polymer-Lipid-Nanostruktur, die dem Transportsystem seine bemerkenswerten Funktionen verleiht, wurde elektronen- und fluoreszenzmikroskopisch charakterisiert (rechts). Citing Literature Supporting Information Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Filename Description ange_201101554_sm_miscellaneous_information.pdf64 KB miscellaneous_information Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume123, Issue31July 25, 2011Pages 7165-7169 This is the German version of Angewandte Chemie. Note for articles published since 1962: Do not cite this version alone. Take me to the International Edition version with citable page numbers, DOI, and citation export. We apologize for the inconvenience. RelatedInformation