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Evolution of the mammalian Y chromosome and sex‐determining genes

1998; Wiley; Volume: 281; Issue: 5 Linguagem: Inglês

10.1002/(sici)1097-010x(19980801)281

1097-010X

Jennifer A. Marshall Graves,

Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities

Journal of Experimental ZoologyVolume 281, Issue 5 p. 472-481 Evolution of the mammalian Y chromosome and sex-determining genes Jennifer A. Marshall Graves, Corresponding Author Jennifer A. Marshall Graves [email protected] School of Genetics and Human Variation, La Trobe University, Melbourne, Victoria 3083, AustraliaSchool of Genetics and Human Variation, La Trobe University, Melbourne, Victoria 3083, Australia===Search for more papers by this author Jennifer A. Marshall Graves, Corresponding Author Jennifer A. Marshall Graves [email protected] School of Genetics and Human Variation, La Trobe University, Melbourne, Victoria 3083, AustraliaSchool of Genetics and Human Variation, La Trobe University, Melbourne, Victoria 3083, Australia===Search for more papers by this author First published: 07 December 1998 https://doi.org/10.1002/(SICI)1097-010X(19980801)281:5 3.0.CO;2-BCitations: 63AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Abstract In mammals, male sex determination, as well as spermatogenesis, is controlled by genes on the Y chromosome. Evolutionary comparisons may be used to detect and test candidate genes for these functions, under the hypothesis that the rapid evolution of the mammalian Y chromosome causes it to contain few genes other than those with a critical function in male reproduction. Comparisons of the gene content of sex chromosomes from the three major groups of extant mammals (placentals, marsupials, and monotremes) show that part of the X chromosome, and a corresponding region of the Y, is shared by all mammals and must be very ancient, but part was added relatively recently. Evolution of the mammalian Y took place in several cycles of addition and attrition, as autosomal regions were added to the pseudoautosomal region of one sex chromosome, recombined onto the other, and degraded on the Y. 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