Enzyme-alterable alkylating agents. III. Synthesis, chemical properties, and toxicities of mustards containing enzyme-susceptible ester bonds
1962; Wiley; Volume: 15; Issue: 5 Linguagem: Inglês
10.1002/1097-0142(196209/10)15
ISSN1097-0142
AutoresBenjamin Witten, Samuel Sass, Jacob I. Miller, Charles E. Williamson, Humberto G. Guerrero, Stanley P. Kramer, Robert D. Solomon, Louis E. Goodman, Arnold M. Seligman,
Tópico(s)Chemotherapy-induced cardiotoxicity and mitigation
ResumoCancerVolume 15, Issue 5 p. 1062-1072 ArticleFree Access Enzyme-alterable alkylating agents. III. Synthesis, chemical properties, and toxicities of mustards containing enzyme-susceptible ester bonds Benjamin Witten PH.D., Benjamin Witten PH.D. Departments of Surgery and Pathology, Sinai Hospital of Baltimore, Inc., Belvedere Ave. at Greenspring, Baltimore 15, Md., the Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Md., and the Chemical Research Division, Army Chemical Research and Development Laboratories, Army Chemical Center, MdSearch for more papers by this authorSamuel Sass B.S., Samuel Sass B.S. Departments of Surgery and Pathology, Sinai Hospital of Baltimore, Inc., Belvedere Ave. at Greenspring, Baltimore 15, Md., the Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Md., and the Chemical Research Division, Army Chemical Research and Development Laboratories, Army Chemical Center, MdSearch for more papers by this authorJacob I. Miller B.S., Jacob I. Miller B.S. Departments of Surgery and Pathology, Sinai Hospital of Baltimore, Inc., Belvedere Ave. at Greenspring, Baltimore 15, Md., the Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Md., and the Chemical Research Division, Army Chemical Research and Development Laboratories, Army Chemical Center, MdSearch for more papers by this authorCharles E. Williamson B.S., Charles E. Williamson B.S. Departments of Surgery and Pathology, Sinai Hospital of Baltimore, Inc., Belvedere Ave. at Greenspring, Baltimore 15, Md., the Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Md., and the Chemical Research Division, Army Chemical Research and Development Laboratories, Army Chemical Center, MdSearch for more papers by this authorHumberto G. Guerrero B.S., Humberto G. Guerrero B.S. Departments of Surgery and Pathology, Sinai Hospital of Baltimore, Inc., Belvedere Ave. at Greenspring, Baltimore 15, Md., the Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Md., and the Chemical Research Division, Army Chemical Research and Development Laboratories, Army Chemical Center, MdSearch for more papers by this authorStanley P. Kramer PH.D., Stanley P. Kramer PH.D. Departments of Surgery and Pathology, Sinai Hospital of Baltimore, Inc., Belvedere Ave. at Greenspring, Baltimore 15, Md., the Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Md., and the Chemical Research Division, Army Chemical Research and Development Laboratories, Army Chemical Center, MdSearch for more papers by this authorRobert D. Solomon M.D., Robert D. Solomon M.D. Departments of Surgery and Pathology, Sinai Hospital of Baltimore, Inc., Belvedere Ave. at Greenspring, Baltimore 15, Md., the Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Md., and the Chemical Research Division, Army Chemical Research and Development Laboratories, Army Chemical Center, MdSearch for more papers by this authorLouis E. Goodman M.D., Louis E. Goodman M.D. Departments of Surgery and Pathology, Sinai Hospital of Baltimore, Inc., Belvedere Ave. at Greenspring, Baltimore 15, Md., the Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Md., and the Chemical Research Division, Army Chemical Research and Development Laboratories, Army Chemical Center, MdSearch for more papers by this authorArnold M. Seligman M.D., Arnold M. Seligman M.D. Departments of Surgery and Pathology, Sinai Hospital of Baltimore, Inc., Belvedere Ave. at Greenspring, Baltimore 15, Md., the Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Md., and the Chemical Research Division, Army Chemical Research and Development Laboratories, Army Chemical Center, MdSearch for more papers by this author Benjamin Witten PH.D., Benjamin Witten PH.D. Departments of Surgery and Pathology, Sinai Hospital of Baltimore, Inc., Belvedere Ave. at Greenspring, Baltimore 15, Md., the Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Md., and the Chemical Research Division, Army Chemical Research and Development Laboratories, Army Chemical Center, MdSearch for more papers by this authorSamuel Sass B.S., Samuel Sass B.S. Departments of Surgery and Pathology, Sinai Hospital of Baltimore, Inc., Belvedere Ave. at Greenspring, Baltimore 15, Md., the Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Md., and the Chemical Research Division, Army Chemical Research and Development Laboratories, Army Chemical Center, MdSearch for more papers by this authorJacob I. Miller B.S., Jacob I. Miller B.S. Departments of Surgery and Pathology, Sinai Hospital of Baltimore, Inc., Belvedere Ave. at Greenspring, Baltimore 15, Md., the Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Md., and the Chemical Research Division, Army Chemical Research and Development Laboratories, Army Chemical Center, MdSearch for more papers by this authorCharles E. Williamson B.S., Charles E. Williamson B.S. Departments of Surgery and Pathology, Sinai Hospital of Baltimore, Inc., Belvedere Ave. at Greenspring, Baltimore 15, Md., the Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Md., and the Chemical Research Division, Army Chemical Research and Development Laboratories, Army Chemical Center, MdSearch for more papers by this authorHumberto G. Guerrero B.S., Humberto G. Guerrero B.S. Departments of Surgery and Pathology, Sinai Hospital of Baltimore, Inc., Belvedere Ave. at Greenspring, Baltimore 15, Md., the Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Md., and the Chemical Research Division, Army Chemical Research and Development Laboratories, Army Chemical Center, MdSearch for more papers by this authorStanley P. Kramer PH.D., Stanley P. Kramer PH.D. Departments of Surgery and Pathology, Sinai Hospital of Baltimore, Inc., Belvedere Ave. at Greenspring, Baltimore 15, Md., the Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Md., and the Chemical Research Division, Army Chemical Research and Development Laboratories, Army Chemical Center, MdSearch for more papers by this authorRobert D. Solomon M.D., Robert D. Solomon M.D. Departments of Surgery and Pathology, Sinai Hospital of Baltimore, Inc., Belvedere Ave. at Greenspring, Baltimore 15, Md., the Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Md., and the Chemical Research Division, Army Chemical Research and Development Laboratories, Army Chemical Center, MdSearch for more papers by this authorLouis E. Goodman M.D., Louis E. Goodman M.D. Departments of Surgery and Pathology, Sinai Hospital of Baltimore, Inc., Belvedere Ave. at Greenspring, Baltimore 15, Md., the Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Md., and the Chemical Research Division, Army Chemical Research and Development Laboratories, Army Chemical Center, MdSearch for more papers by this authorArnold M. Seligman M.D., Arnold M. Seligman M.D. Departments of Surgery and Pathology, Sinai Hospital of Baltimore, Inc., Belvedere Ave. at Greenspring, Baltimore 15, Md., the Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Md., and the Chemical Research Division, Army Chemical Research and Development Laboratories, Army Chemical Center, MdSearch for more papers by this author First published: September/October 1962 https://doi.org/10.1002/1097-0142(196209/10)15:5 3.0.CO;2-1Citations: 7AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat References 1 Cohen, R. B., Nachlas, M. M., and Seligman, A. M.: Histochemical demonstration of esterase in malignant tumors. Cancer Res. 11: 709–711, 1951. 2 Karnofsky, D. A., Burchenal, J. H., Ormsbee, R. A., Cornman, I., and Rhoads, C. P.: Experimental observations on use of nitrogen mustards in treatment of neoplastic disease. In F. R. Moulton, Ed.: Approaches to Tumor Chemotherapy. Washington, D.C. American Association for the Advancement of Science. 1947; pp. 295–305. 3 Nachlas, M. M., and Seligman, A. M.: Evidence for specificity of esterase and lipase by use of 3 chromogenic substrates. J. Biol. Chem. 181: 343–355, 1949. 4 Seligman, A. M., Kramer, S. P., Goodman, L. E., Gaby, S. D., Bakal, D., Solomon, R. D., Miller, J. I., Sass, S., Williamson, C., and Witten, B.: Preliminary clinical trial of new possible cancer chemotherapeutic agent based upon enzymatic detoxification by normal epithelial tissue. Proc. Am. A. Cancer Res. 3: 63, 1959–1960. 5 Seligman, A. M., Rutenburg, A. M., Persky, L., and Friedman, O. M.: Effect of 2-chloro-2′-hydroxydiethyl sulfide (hemisulfur mustard) on carcinomatosis with ascites. Cancer 5: 354–363, 1952. 6 Witten, B., Williamson, C. E., Sass, S., Miller, J. I., Best, R., Wicks, G. E. Jr., Kramer, S. P., Weinberg, T., Solomon, R. D., Goodman, L. E., and Seligman, A. M.: Enzyme-alterable alkylating agents; I, synthesis, chemical properties, and toxicities of sulfur mustards containing enzyme-susceptible amide bonds. Cancer 15: 1041–1055, 1962. Citing Literature Volume15, Issue5September/October 1962Pages 1062-1072 ReferencesRelatedInformation
Referência(s)