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Catalytic Asymmetric Michael Reactions of Acetaldehyde

2008; Wiley; Volume: 120; Issue: 25 Linguagem: Inglês

10.1002/ange.200800847

1521-3757

Patricia García‐García, Arnaud Ladépêche, Rajkumar Halder, Benjamin List,

Chemical Synthesis and Reactions

Angewandte ChemieVolume 120, Issue 25 p. 4797-4799 Zuschrift Catalytic Asymmetric Michael Reactions of Acetaldehyde† Patricia García-García Dr., Patricia García-García Dr. Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470 Mülheim an der Ruhr, Germany, Fax: (+49) 208-306-2999Search for more papers by this authorArnaud Ladépêche Dr., Arnaud Ladépêche Dr. Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470 Mülheim an der Ruhr, Germany, Fax: (+49) 208-306-2999Search for more papers by this authorRajkumar Halder Dr., Rajkumar Halder Dr. Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470 Mülheim an der Ruhr, Germany, Fax: (+49) 208-306-2999Search for more papers by this authorBenjamin List Prof. Dr., Benjamin List Prof. Dr. list@mpi-muelheim.mpg.de Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470 Mülheim an der Ruhr, Germany, Fax: (+49) 208-306-2999Search for more papers by this author Patricia García-García Dr., Patricia García-García Dr. Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470 Mülheim an der Ruhr, Germany, Fax: (+49) 208-306-2999Search for more papers by this authorArnaud Ladépêche Dr., Arnaud Ladépêche Dr. Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470 Mülheim an der Ruhr, Germany, Fax: (+49) 208-306-2999Search for more papers by this authorRajkumar Halder Dr., Rajkumar Halder Dr. Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470 Mülheim an der Ruhr, Germany, Fax: (+49) 208-306-2999Search for more papers by this authorBenjamin List Prof. Dr., Benjamin List Prof. Dr. list@mpi-muelheim.mpg.de Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470 Mülheim an der Ruhr, Germany, Fax: (+49) 208-306-2999Search for more papers by this author First published: 03 June 2008 https://doi.org/10.1002/ange.200800847Citations: 90 † We thank Jutta Rosentreter for technical assistance. Generous support by the Max-Planck-Society, the DFG (SPP 1179, Organokatalyse), Novartis (Young Investigator Award to B.L.), AstraZeneca (Award in Organic Chemistry to B.L.), Secretaría de Estado de Universidades e Investigación del Ministerio de Educación y Ciencia (Fellowship to P.G.G.), and the Fonds der Chemischen Industrie is gratefully acknowledged. Read the full textAboutPDF ToolsRequest permissionAdd to favorites ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Graphical Abstract Acetaldehyd als Nucleophil in der asymmetrischen Katalyse: Ein Silylprolinol-Derivat (TMS=Trimethylsilyl) katalysiert die Michael-Addition von Acetaldehyd mit aromatischen und aliphatischen Nitroolefinen in hervorragenden Enantioselektivitäten. Die Reaktion wurde zur Synthese dreier pharmazeutischer Wirkstoffe und eines enantiomerenreinen 3-substituierten Pyrrolidins angewendet. Citing Literature Supporting Information Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2001/2008/z800847_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume120, Issue25June 9, 2008Pages 4797-4799 This is the German version of Angewandte Chemie. Note for articles published since 1962: Do not cite this version alone. Take me to the International Edition version with citable page numbers, DOI, and citation export. We apologize for the inconvenience. RelatedInformation