A Bond for a Lifetime: Employing Membrane Nanotubes from Living Cells to Determine Receptor–Ligand Kinetics
2008; Wiley; Volume: 120; Issue: 50 Linguagem: Inglês
10.1002/ange.200803552
ISSN1521-3757
AutoresMichael Krieg, Jonne Helenius, Carl‐Philipp Heisenberg, Daniel J. Müller,
Tópico(s)Advanced biosensing and bioanalysis techniques
ResumoAngewandte ChemieVolume 120, Issue 50 p. 9921-9923 Zuschrift A Bond for a Lifetime: Employing Membrane Nanotubes from Living Cells to Determine Receptor–Ligand Kinetics† Michael Krieg, Michael Krieg Dept. of Cellular Machines, Biotechnology Center, University of Technology, 01307 Dresden (Germany), Fax: (+49) 351-463-40330Search for more papers by this authorJonne Helenius Dr., Jonne Helenius Dr. Dept. of Cellular Machines, Biotechnology Center, University of Technology, 01307 Dresden (Germany), Fax: (+49) 351-463-40330Search for more papers by this authorCarl-Philipp Heisenberg Dr., Carl-Philipp Heisenberg Dr. Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden (Germany)Search for more papers by this authorDaniel J. Muller Prof., Daniel J. Muller Prof. [email protected] Dept. of Cellular Machines, Biotechnology Center, University of Technology, 01307 Dresden (Germany), Fax: (+49) 351-463-40330Search for more papers by this author Michael Krieg, Michael Krieg Dept. of Cellular Machines, Biotechnology Center, University of Technology, 01307 Dresden (Germany), Fax: (+49) 351-463-40330Search for more papers by this authorJonne Helenius Dr., Jonne Helenius Dr. Dept. of Cellular Machines, Biotechnology Center, University of Technology, 01307 Dresden (Germany), Fax: (+49) 351-463-40330Search for more papers by this authorCarl-Philipp Heisenberg Dr., Carl-Philipp Heisenberg Dr. Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden (Germany)Search for more papers by this authorDaniel J. Muller Prof., Daniel J. Muller Prof. [email protected] Dept. of Cellular Machines, Biotechnology Center, University of Technology, 01307 Dresden (Germany), Fax: (+49) 351-463-40330Search for more papers by this author First published: 26 November 2008 https://doi.org/10.1002/ange.200803552Citations: 5 † This project was supported by the European Union, the BMBF, the Free State of Saxony, and the Boehringer Ingelheim Fonds (M.K.). Read the full textAboutPDF ToolsRequest permissionAdd to favorites ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Graphical Abstract Biologische Bindungen: Werden Zellen vom Substrat getrennt, so bilden sich membranöse Nanoröhren (siehe Bild), die konstante Rückstellungskräfte applizieren. Befinden sich an der Spitze dieser Nanoröhren spezifische Rezeptor-Ligand-Bindungen, so ist deren Lebensdauer über die konstante Kraft bestimmt. Da Nanoröhren aus lebenden Zellen extrahiert werden, können damit zelluläre Bindungen in Abhängigkeit von zellulären Prozessen bestimmt werden. Supporting Information Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Filename Description ange_200803552_sm_miscellaneous_information.pdf206.9 KB miscellaneous information Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. References 1G. I. Bell, Science 1978, 200, 618. 10.1126/science.347575 CASPubMedWeb of Science®Google Scholar 2E. A. Evans, D. A. Calderwood, Science 2007, 316, 1148. 10.1126/science.1137592 CASPubMedWeb of Science®Google Scholar 3X. Chen, B. M. Gumbiner, J. Cell Biol. 2006, 174, 301. 10.1083/jcb.200602062 CASPubMedWeb of Science®Google Scholar 4B. T. Marshall, M. Long, J. W. Piper, T. Yago, R. P. McEver, C. Zhu, Nature 2003, 423, 190. 10.1038/nature01605 CASPubMedWeb of Science®Google Scholar 5W. Baumgartner, N. Golenhofen, N. Grundhofer, J. Wiegand, D. Drenckhahn, J. Neurosci. 2003, 23, 11008. CASPubMedWeb of Science®Google Scholar 6W. 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