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Scientific Opinion on the safety and efficacy of l‐threonine produced by Escherichia coli strains NRRL B‐30843, DSM 26131, KCCM11133P or DSM 25085 for all animal species based on a dossier submitted by AMAC EEIG

2015; Wiley; Volume: 13; Issue: 9 Linguagem: Inglês

10.2903/j.efsa.2015.4236

1831-4732

EFSA Panel on Additives and Products or Substances used in Animal Feed,

Agriculture Sustainability and Environmental Impact

EFSA JournalVolume 13, Issue 9 4236 OpinionOpen Access Scientific Opinion on the safety and efficacy of l-threonine produced by Escherichia coli strains NRRL B-30843, DSM 26131, KCCM11133P or DSM 25085 for all animal species based on a dossier submitted by AMAC EEIG EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Corresponding Author EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) FEEDAP@efsa.europa.eu European Food Safety Authority (EFSA), Parma, ItalyFEEDAP@efsa.europa.euSearch for more papers by this author EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Corresponding Author EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) FEEDAP@efsa.europa.eu European Food Safety Authority (EFSA), Parma, ItalyFEEDAP@efsa.europa.euSearch for more papers by this author First published: 29 September 2015 https://doi.org/10.2903/j.efsa.2015.4236Citations: 8 On request from the European Commission. Questions No EFSA-Q-2012-00113, adopted on 9 September 2015. Panel members: Gabriele Aquilina, Vasileios Bampidis, Maria de Lourdes Bastos, Georges Bories, Andrew Chesson, Pier Sandro Cocconcelli, Maria Luisa Fernandez-Cruz, Gerhard Flachowsky, Jürgen Gropp, Boris Kolar, MarylineKouba, Secundino Lopez Puente, Marta Lopez-Alonso, Alberto Mantovani, Baltasar Mayo, Fernando Ramos, Guido Rychen, Maria Saarela, Roberto Edoardo Villa, Robert John Wallace and Pieter Acknowledgement: The Panel wishes to thank the members of the Working Group on Amino acids and the Working Group, including Paul Brantom, Lucio Costa, Noël Dierick, Lubomir Leng and Giovanna Martelli, and the members of the WorkingGroup on Genetically Modified Microorganisms of FEEDAP, including Pier Sandro Cocconcelli, Boet Glandorf, Lieve Herman SirpaKärenlampi and Christoph Tebbe, for the preparatory work on this scientific opinion. Amended: 24 March 2020 AboutPDF ToolsExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Abstract This opinion concerns l-threonine as a feed additive produced by four different strains derived from Escherichia coli K-12. Three strains are genetically modified (GM): NRRL B-30843, KCCM11133P and DSM 26131. l-Threonine produced by E. coli DSM 26131 could not be assessed because of the insufficient molecular characterisation of the genetic modification, and the lack of data on both the absence of the production strain and its recombinant DNA from the final product. No safety concerns were found in the products related to the genetic modification of the other GM strains or to antibiotic resistance of the producer strains. l-Threonine products made by fermentation using E. coli strains NRRL B-30843, KCCM11133P and DSM 25085 are free of the production strain and have a high purity ( 98.8 %).l-Threonine, technically pure, produced by E. coli strains NRRL B-30843, KCCM11133P and DSM 25085 is safe for the target animals when used in appropriate amounts to supplement threonine-deficient feeds, for the consumer of animal products and for the environment. The FEEDAP Panel considers that l-threonine produced by E. colistrains NRRL B-30843, KCCM11133Por DSM 25085 is not irritant to eyes and skin, and is nota skin sensitiser. There is no risk from inhalation of l-threonine, but concerns may arise from the content of endotoxins in the products. 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Inflammatory Response, 50, 254– 261. Citing Literature Volume13, Issue9September 20154236 ReferencesRelatedInformation