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Neuroblastoma

1962; Elsevier BV; Volume: 61; Issue: 3 Linguagem: Inglês

10.1016/s0022-3476(62)80379-5

1097-6833

Harold W. Dargeon,

Neuroendocrine Tumor Research Advances

The frequency with which childhood cancers are observed increases annually. In the experience of the Pediatric Department of Memorial Hospital for Cancer and Allied Diseases neuroblastoma is foremost in incidence among the solid malignant tumors that occur in children. This review of 236 cases emphasizes features of clinical significance in diagnosis, therapy, and prognosis. The diagnosis is quite readily made in some instances, while in others it may present insurmountable difficulties. Plans for treatment require considerations regarding the site, or in metastatic cases sites, the operability of the tumor, and the use of pre- or postoperative irradiation and chemotherapy. The method of management must often be altered by the problems encountered in the individual case. There is now a larger number of survivors and metastatic disease does not always indicate a fatal prognosis. Recognition of the not infrequent bizarre clinical course, at times resulting in even “spontaneous” arrest, makes caution in the appraisal of therapeutic successes mandatory. The frequency with which childhood cancers are observed increases annually. In the experience of the Pediatric Department of Memorial Hospital for Cancer and Allied Diseases neuroblastoma is foremost in incidence among the solid malignant tumors that occur in children. This review of 236 cases emphasizes features of clinical significance in diagnosis, therapy, and prognosis. The diagnosis is quite readily made in some instances, while in others it may present insurmountable difficulties. Plans for treatment require considerations regarding the site, or in metastatic cases sites, the operability of the tumor, and the use of pre- or postoperative irradiation and chemotherapy. The method of management must often be altered by the problems encountered in the individual case. There is now a larger number of survivors and metastatic disease does not always indicate a fatal prognosis. Recognition of the not infrequent bizarre clinical course, at times resulting in even “spontaneous” arrest, makes caution in the appraisal of therapeutic successes mandatory.