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Efficacy of very high dose steroid treatment in a case of Landau-Kleffnersyndrome

2007; Wiley; Volume: 48; Issue: 9 Linguagem: Inglês

10.1111/j.1469-8749.2006.tb01364.x

1469-8749

Siobhán Gallagher, Shelley Weiss, Karen Harman, Shay Menascu,

Neuroscience and Neuropharmacology Research

Developmental Medicine & Child NeurologyVolume 48, Issue 9 p. 766-769 Free Access Efficacy of very high dose steroid treatment in a case of Landau-Kleffnersyndrome Siobhan Gallagher MB, Corresponding Author Siobhan Gallagher MB Division of Neurology, Department of Paediatrics, The Hospital for Sick Children, University of Toronto*Correspondence to first author at Department of Paediatrics, Letterkenny General Hospital, Letterkenny, Co. Donegal, Republic of Ireland. E-mail: sgallagher@ireland.comSearch for more papers by this authorShelley Weiss MD, Shelley Weiss MD Division of Neurology, Department of Paediatrics, The Hospital for Sick Children, University of TorontoSearch for more papers by this authorKaren E Harman MD, Karen E Harman MD Division of Child Development, Department of Paediatrics, McMaster Children's Hospital, McMaster University, Hamilton, OntarioSearch for more papers by this authorShay Menascu MD, Shay Menascu MD Division of Neurology, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Canada.Search for more papers by this author Siobhan Gallagher MB, Corresponding Author Siobhan Gallagher MB Division of Neurology, Department of Paediatrics, The Hospital for Sick Children, University of Toronto*Correspondence to first author at Department of Paediatrics, Letterkenny General Hospital, Letterkenny, Co. Donegal, Republic of Ireland. E-mail: sgallagher@ireland.comSearch for more papers by this authorShelley Weiss MD, Shelley Weiss MD Division of Neurology, Department of Paediatrics, The Hospital for Sick Children, University of TorontoSearch for more papers by this authorKaren E Harman MD, Karen E Harman MD Division of Child Development, Department of Paediatrics, McMaster Children's Hospital, McMaster University, Hamilton, OntarioSearch for more papers by this authorShay Menascu MD, Shay Menascu MD Division of Neurology, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Canada.Search for more papers by this author First published: 13 February 2007 https://doi.org/10.1111/j.1469-8749.2006.tb01364.xCitations: 2AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Landau-Kleffner syndrome (LKS) is an acquired childhood aphasia associated with paroxysmal bitemporal electroencephalogram (EEG) abnormalities and, sometimes, clinical seizures. We report the case of a female aged 5 years 6 months who presented clinically with apparent hearing loss, deterioration in speech, and seizure activity over 12 days. The female had previous detailed speech/language assessments at 3 to 4 years of age due to articulation delay. LKS was diagnosed on EEG with bitemporal spike and wave activity during sleep. The patient was treated with high dose prednisolone 3mg/kg/day, intensive speech/language therapy, and followed a modified educational program. We recorded a marked regression in receptive and expressive language skills, as well as her speech, language, and cognitive profiles before and during treatment with prednisolone, during an 18-month follow-up period. The patient demonstrated an excellent clinical response highlighting the importance of a multidisciplinary approach to management of LKS. Citing Literature Volume48, Issue9September 2006Pages 766-769 ReferencesRelatedInformation