A dedicated neonatal brain imaging system
2017; Wiley; Volume: 78; Issue: 2 Linguagem: Inglês
10.1002/mrm.26844
ISSN1522-2594
AutoresEmer Hughes, Tobias Winchman, Francesco Padormo, Rui Teixeira, Julia Wurie, Maryanne Sharma, Matthew P. Fox, Jana Hutter, Lucilio Cordero‐Grande, Anthony N. Price, Joanna Allsop, Jose Bueno-Conde, Nora Tusor, Tomoki Arichi, A. D. Edwards, Mary Rutherford, Serena J. Counsell, Joseph V. Hajnal,
Tópico(s)Atomic and Subatomic Physics Research
ResumoPurpose The goal of the Developing Human Connectome Project is to acquire MRI in 1000 neonates to create a dynamic map of human brain connectivity during early development. High-quality imaging in this cohort without sedation presents a number of technical and practical challenges. Methods We designed a neonatal brain imaging system (NBIS) consisting of a dedicated 32-channel receive array coil and a positioning device that allows placement of the infant's head deep into the coil for maximum signal-to-noise ratio (SNR). Disturbance to the infant was minimized by using an MRI-compatible trolley to prepare and transport the infant and by employing a slow ramp-up and continuation of gradient noise during scanning. Scan repeats were minimized by using a restart capability for diffusion MRI and retrospective motion correction. We measured the 1) SNR gain, 2) number of infants with a completed scan protocol, and 3) number of anatomical images with no motion artifact using NBIS compared with using an adult 32-channel head coil. Results The NBIS has 2.4 times the SNR of the adult coil and 90% protocol completion rate. Conclusion The NBIS allows advanced neonatal brain imaging techniques to be employed in neonatal brain imaging with high protocol completion rates. Magn Reson Med 78:794–804, 2017. © 2016 International Society for Magnetic Resonance in Medicine
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