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De Novo Sequence and Copy Number Variants Are Strongly Associated with Tourette Disorder and Implicate Cell Polarity in Pathogenesis

2018; Cell Press; Volume: 25; Issue: 12 Linguagem: Inglês

10.1016/j.celrep.2018.12.024

2639-1856

Sheng Wang, Jeffrey D. Mandell, Yogesh Kumar, Nawei Sun, Montana T. Morris, Juan David Arbelaez, Cara Nasello, Dong Shan, Clif Duhn, Xin Zhao, Zhiyu Yang, Shanmukha Sampath Padmanabhuni, Dongmei Yu, Robert A. King, Andrea Dietrich, Najah Khalifa, Niklas Dahl, Alden Y. Huang, Benjamin M. Neale, Giovanni Coppola, Carol A. Mathews, Jeremiah M. Scharf, Thomas Fernandez, Joseph D. Buxbaum, Silvia De Rubeis, Dorothy E. Grice, Jinchuan Xing, Gary A. Heiman, Jay A. Tischfield, Peristera Paschou, A. Jeremy Willsey, Matthew W. State,

Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities

(Cell Reports 24, 3441–3454.e1–e12; September 25, 2018) In the originally published version of this article, the secondary author list detailing authors from the associated consortia was omitted due a miscommunication. The secondary author list has now been included with the article online. Cell Press apologizes for this miscommunication. De Novo Sequence and Copy Number Variants Are Strongly Associated with Tourette Disorder and Implicate Cell Polarity in PathogenesisWang et al.Cell ReportsSeptember 25, 2018In BriefWang et al. expand their earlier exome-sequencing work in TD, adding 291 trios and conducting combined analyses suggesting de novo variants carry more risk in individuals with unaffected parents, establishing de novo structural variants as risk factors, identifying CELSR3 as a risk gene, and implicating cell polarity in pathogenesis. Full-Text PDF Open Access