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Controlled Axial Coordination: Solid‐Phase Synthesis and Purification of Metallo‐Radiopharmaceuticals

2008; Wiley; Volume: 120; Issue: 44 Linguagem: Inglês

10.1002/ange.200801936

1521-3757

Helen Betts, Peter J. Barnard, S.R. Bayly, Jonathan R. Dilworth, Antony D. Gee, Jason P. Holland,

Organometallic Complex Synthesis and Catalysis

Angewandte ChemieVolume 120, Issue 44 p. 8544-8547 Zuschrift Controlled Axial Coordination: Solid-Phase Synthesis and Purification of Metallo-Radiopharmaceuticals† Helen M. Betts, Helen M. Betts Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA (UK), Fax: (+44) 1865-272690Search for more papers by this authorPeter J. Barnard Dr., Peter J. Barnard Dr. Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA (UK), Fax: (+44) 1865-272690Search for more papers by this authorSimon R. Bayly Dr., Simon R. Bayly Dr. Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA (UK), Fax: (+44) 1865-272690 Siemens Oxford Molecular Imaging Laboratory, University of Oxford, South Parks Road, Oxford OX1 3QR (UK)Search for more papers by this authorJonathan R. Dilworth Prof., Jonathan R. Dilworth Prof. jon.dilworth@chem.ox.ac.uk Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA (UK), Fax: (+44) 1865-272690 Siemens Oxford Molecular Imaging Laboratory, University of Oxford, South Parks Road, Oxford OX1 3QR (UK)Search for more papers by this authorAntony D. Gee Prof., Antony D. Gee Prof. PET and Radiotracer Development GSK Clinical Imaging Centre, Hammersmith Hospital, Du Cane Road, London, W12 ONN (UK)Search for more papers by this authorJason P. Holland Dr., Jason P. Holland Dr. Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA (UK), Fax: (+44) 1865-272690Search for more papers by this author Helen M. Betts, Helen M. Betts Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA (UK), Fax: (+44) 1865-272690Search for more papers by this authorPeter J. Barnard Dr., Peter J. Barnard Dr. Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA (UK), Fax: (+44) 1865-272690Search for more papers by this authorSimon R. Bayly Dr., Simon R. Bayly Dr. Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA (UK), Fax: (+44) 1865-272690 Siemens Oxford Molecular Imaging Laboratory, University of Oxford, South Parks Road, Oxford OX1 3QR (UK)Search for more papers by this authorJonathan R. Dilworth Prof., Jonathan R. Dilworth Prof. jon.dilworth@chem.ox.ac.uk Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA (UK), Fax: (+44) 1865-272690 Siemens Oxford Molecular Imaging Laboratory, University of Oxford, South Parks Road, Oxford OX1 3QR (UK)Search for more papers by this authorAntony D. Gee Prof., Antony D. Gee Prof. PET and Radiotracer Development GSK Clinical Imaging Centre, Hammersmith Hospital, Du Cane Road, London, W12 ONN (UK)Search for more papers by this authorJason P. Holland Dr., Jason P. Holland Dr. Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA (UK), Fax: (+44) 1865-272690Search for more papers by this author First published: 15 October 2008 https://doi.org/10.1002/ange.200801936Citations: 4 † H.M.B. thanks GlaxoSmithKline for funding. P.J.B. thanks GlaxoSmithKline for a fellowship. S.R.B. thanks DTI and Siemens Molecular Imaging Ltd for a fellowship. J.P.H. thanks Merton College and the EPSRC for funding. We thank Prof. Jennifer Green and Philip Waghorn for helpful discussions, Dr. Christoph Salzmann for assistance with Raman spectroscopy, and the Oxford Supercomputing Centre. Read the full textAboutPDF ToolsRequest permissionAdd to favorites ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Graphical Abstract So geht's leichter: Die kontrollierte axiale Koordination pseudo-quadratisch-planarer Zink(II)-Komplexe an ein 4-(Dimethylamino)pyridin-funktionalisiertes Polystyrolharz erleichtert die Synthese (durch Transmetallierung) und Reinigung (durch selektive Ligation) von Metalloradiopharmazeutika. Diese Komplexe sollten sich als Bildgebungsreagentien für die Positronenemissionstomographie eignen. Citing Literature Supporting Information Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Filename Description ange_200801936_sm_miscellaneous_information.pdf1.6 MB miscellaneous information Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume120, Issue44October 20, 2008Pages 8544-8547 This is the German version of Angewandte Chemie. Note for articles published since 1962: Do not cite this version alone. Take me to the International Edition version with citable page numbers, DOI, and citation export. We apologize for the inconvenience. RelatedInformation