Letter to the Editor: Re: The Clinical Effect of Scaling and Root Planing and the Concomitant Administration of Systemic Amoxicillin and Metronidazole: A Systematic Review; Re: Effectiveness of Systemic Amoxicillin/Metronidazole as Adjunctive Therapy to Scaling and Root Planing in the Treatment of Chronic Periodontitis: A Systematic Review and Meta‐Analysis; Re: Effectiveness of Systemic Amoxicillin/Metronidazole as an Adjunctive Therapy to Full‐Mouth Scaling and Root Planing in the Treatment …
2014; Wiley; Volume: 85; Issue: 3 Linguagem: Inglês
10.1902/jop.2014.130379
ISSN1943-3670
AutoresHans R. Preus, Anne Aamdal Scheie, Vibeke Bælum,
Tópico(s)HIV/AIDS oral health manifestations
ResumoJournal of PeriodontologyVolume 85, Issue 3 p. 374-384 News and Views Letter to the Editor: Re: The Clinical Effect of Scaling and Root Planing and the Concomitant Administration of Systemic Amoxicillin and Metronidazole: A Systematic Review; Re: Effectiveness of Systemic Amoxicillin/Metronidazole as Adjunctive Therapy to Scaling and Root Planing in the Treatment of Chronic Periodontitis: A Systematic Review and Meta-Analysis; Re: Effectiveness of Systemic Amoxicillin/Metronidazole as an Adjunctive Therapy to Full-Mouth Scaling and Root Planing in the Treatment of Aggressive Periodontitis: A Systematic Review and Meta-Analysis Hans R. Preus, Hans R. Preus Department of Periodontology, Institute of Clinical Odontology, Faculty of Dentistry, University of Oslo, Oslo, NorwaySearch for more papers by this authorAnne Aamdal Scheie, Anne Aamdal Scheie Department of Microbiology, Institute of Oral Biology, Faculty of Dentistry, University of Oslo; andSearch for more papers by this authorVibeke Baelum, Vibeke Baelum Department of Dentistry, Faculty of Health Sciences, Aarhus University, Aarhus, Denmark.Search for more papers by this author Hans R. Preus, Hans R. Preus Department of Periodontology, Institute of Clinical Odontology, Faculty of Dentistry, University of Oslo, Oslo, NorwaySearch for more papers by this authorAnne Aamdal Scheie, Anne Aamdal Scheie Department of Microbiology, Institute of Oral Biology, Faculty of Dentistry, University of Oslo; andSearch for more papers by this authorVibeke Baelum, Vibeke Baelum Department of Dentistry, Faculty of Health Sciences, Aarhus University, Aarhus, Denmark.Search for more papers by this author First published: 01 March 2014 https://doi.org/10.1902/jop.2014.130379Citations: 23Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat REFERENCES 1Zandbergen D, Slot DE, Cobb CM, Van der Weijden FA. The clinical effect of scaling and root planing and the concomitant administration of systemic amoxicillin and metronidazole: A systematic review. J Periodontol 2013; 84: 332–351. 2Sgolastra F, Petrucci A, Gatto R, Monaco A. Effectiveness of systemic amoxicillin/metronidazole as an adjunctive therapy to full-mouth scaling and root planing in the treatment of aggressive periodontitis: A systematic review and meta-analysis. J Periodontol 2012; 83: 731–743. 3Sgolastra F, Gatto R, Petrucci A, Monaco A. Effectiveness of systemic amoxicillin/metronidazole as adjunct therapy to scaling and root planing in the treatment of chronic periodontitis: A systematic review and meta-analysis. J Periodontol 2012; 83: 1257–1269. 4Becker W, Becker BE, Caffesse R, et al. A longitudinal study comparing scaling, osseous surgery, and modified Widman procedures: Results after 5 years. J Periodontol 2001; 72: 1675–1684. 5Cobb CM. Clinical significance of non-surgical periodontal therapy: An evidence-based perspective of scaling and root planing. J Clin Periodontol 2002; 29(Suppl. 2): 6–16. 6Pawlowski AP, Chen A, Hacker BM, Mancl LA, Page RC, Roberts FA. Clinical effects of scaling and root planing on untreated teeth. J Clin Periodontol 2005; 32: 21–28. 7Brochut PF, Marin I, Baehni P, Mombelli A. Predictive value of clinical and microbiological parameters for the treatment outcome of scaling and root planing. J Clin Periodontol 2005; 32: 695–701. 8Rosalem W, Rescala B, Teles RP, Fischer RG, Gustafsson A, Figueredo CM. Effect of non-surgical treatment on chronic and aggressive periodontitis: Clinical, immunologic, and microbiologic findings. J Periodontol 2011; 82: 979–989. 9Walker CB, Gordon JM, Magnusson I, Clark WB. A role for antibiotics in the treatment of refractory periodontitis. J Periodontol 1993; 64(Suppl. 8): 772–781. 10Lang NP, Joss A, Orsanic T, Gusberti FA, Siegrist BE. Bleeding on probing, a predictor for the progression of periodontal disease? J Clin Periodontol 1986; 13: 590–596. 11Haffajee AD, Socransky SS, Gunsolley JC. Systemic anti-infective periodontal therapy. A systematic review. Ann Periodontol 2003; 8: 115–181. 12Herrera D, Sanz M, Jepsen S, Needleman I, Roldán S. A systematic review on the effect of systemic antimicrobials as an adjunct to scaling and root planing in periodontitis patients. J Clin Periodontol 2002; 29(Suppl. 3): 136–159. 13Slots J, Ting M. Systemic antibiotics in the treatment of periodontal disease. Periodontol 2000 2002; 28: 106–176. 14Slots J. Systemic antibiotics in periodontics. J Periodontol 2003; 74: 1415–1422. 15Mombelli A. Heresy? Treatment of chronic periodontitis with systemic antibiotics only. J Clin Periodontol 2006; 33: 661–662. 16Aimetti M, Romano F, Guzzi N, Carnevale G. Full-mouth disinfection and systemic antimicrobial therapy in generalized aggressive periodontitis: A randomized placebo-controlled trial. J Clin Periodontol 2012; 39: 284–294. 17Silva MP, Feres M, Sirotto TAO, et al. Clinical and microbiological benefits of metronidazole alone or with amoxicillin as adjuncts in the treatment of chronic periodontitis: A randomized placebo-controlled clinical trial. J Clin Periodontol 2011; 38: 828–837. 18Yek EC, Cintan S, Topcuoglu N, Kulekci G, Issever H, Kantarci A. Efficacy of amoxicillin and metronidazole combination for the management of generalized aggressive periodontitis. J Periodontol 2010; 81: 964–974. 19Mombelli A, Cionca N, Almaglouth A. Does adjunctive antimicrobial therapy reduce the perceived need for periodontal surgery? Periodontol 2000 2011; 55: 205–216. 20Bittner J, Munteanu V. Potentiating action of combining metronidazole and penicillin against C. perfringens in vitro. In: S Finegold, McFadzean JA, FJC Roe, eds. Metronidazole: Proceedings of the International Metronidazole Conference (Québec, Canada, May 26-28, 1976). Amsterdam: Excerpta Medica; 1977: 293–298. 21Van Winkelhoff AJ, Rodenburg JP, Goené RJ, Abbas F, Winkel EG, de Graaff J. Metronidazole plus amoxicillin in the treatment of Actinobacillus actinomycetemcomitans associated periodontitis. J Clin Periodontol 1989; 16: 128–131. 22Socransky SS, Haffajee AD. Periodontal microbial ecology. Microbiology of periodontal diseases. Periodontol 2000 2005; 38: 135–187. 23 World Health Organization. The Evolving Threat of Antimicrobial Resistance: Options for Action. Geneva, Switzerland: World Health Organization; 2012. 24Bronzwaer S, Lönnroth A, Haigh R. The European community strategy against antimicrobial resistance. Euro Surveill 2004; 9: 441. 25 European Center for Disease Prevention and Control. Strategies for Disease-Specific Programs: 2010-2013. Stockholm: European Center for Disease Prevention and Control; 2010. 26Jorgensen MG, Slots J. Responsible use of antimicrobials in periodontics. J Calif Dent Assoc 2000; 28: 185–193. 27Veloo AC, Seme K, Raangs E, et al. Antibiotic susceptibility profiles of oral pathogens. Int J Antimicrob Agents 2012; 40: 450–454. 28Van Winkelhoff AJ, Rams TE, Slots J. Systemic antibiotic therapy in periodontics. Periodontol 2000 1996; 10: 45–78. 29Moher D, Tetzlaff J, Tricco AC, Sampson M, Altman DG. Epidemiology and reporting characteristics of systematic reviews. PLoS Med 2007; 4: e78. 30Lundh A, Knijnenburg SL, Jorgensen AW, van Dalen EC, Kremer LC. Quality of systematic reviews in pediatric oncology — a systematic review. Cancer Treat Rev 2009; 35: 645–652. 31Baderstein A, Nilveus R, Egelberg J. Effect of non-surgical periodontal therapy. II. J Clin Periodontol 1984; 11: 63–76. 32Claffey N, Loos B, Gantes B, Martin M, Heins P, Egelberg J. The relative effects of therapy and periodontal disease on loss of probing attachment after root debridement. J Clin Periodontol 1988; 17: 108–114. 33Bowers GM, Chadroff B, Carnevale R, et al. Histologic evaluation of new attachment apparatus formation in humans. Part I. J Periodontol 1989; 60: 664–674. 34Goodson JM, Haffajee AD, Socransky SS, et al. Control of periodontal infections: A randomized controlled trial. I. The primary outcome attachment gain and pocket depth reduction at treated sites. J Clin Periodontol 2012; 39: 526–536. 35Valenza G, Veihelmann S, Peplies J, et al. Microbial changes in periodontitis successfully treated with mechanical plaque removal and systemic amoxicillin and metronidazole. Int J Med Microbiol 2009; 299: 427–438. 36Giannopoulou C, Andersen E, Brochut P, Plagnat D, Mombelli A. Enamel matrix derivative and systemic antibiotics as adjuncts to non-surgical periodontal treatment: Biologic response. J Periodontol 2006; 77: 707–713. 37Mombelli A, Brochut P, Plagnat D, Casagni F, Giannopoulou C. Enamel matrix derivative and systemic antibiotics as adjuncts to non-surgical periodontal treatment: Clinical effects. J Clin Periodontol 2005; 32: 225–230. 38Ehmke B, Moter A, Beikler T, Milian E, Flemmig TF. Adjunctive antimicrobial therapy of periodontitis: Long-term effects on disease progression and oral colonization. J Periodontol 2005; 76: 749–759. 39Berglundh T, Krok L, Liljenberg B, Westfelt E, Serino G, Lindhe J. The use of metronidazole and amoxicillin in the treatment of advanced periodontal disease. A prospective, controlled clinical trial. J Clin Periodontol 1998; 25: 354–362. 40Walker C, Karpinia K. Rationale for use of antibiotics in periodontics. J Periodontol 2002; 73: 1188–1196. 41Aimetti M, Romano F, Guzzi N, Carnevale G. Full-mouth disinfection and systemic antimicrobial therapy in generalized aggressive periodontitis: A randomized placebo-controlled trial. J Clin Periodontol 2012; 39: 284–294. 42Preus HR, Gunleiksrud TM, Sandvik L, Gjermo P, Baelum V. A randomized, double-masked clinical trial comparing four periodontitis treatment strategies: 1-year clinical results. J Periodontol 2013; 84: 1075–1086. 43Flemmig TF, Milian E, Karch H, Klaiber B. Differential treatment outcome after systemic metronidazole and amoxicillin in patients harboring Actinobacillus actinomycetemcomitans and/or Porphyromonas gingivalis. J Clin Periodontol 1998; 25: 380–387. 44Müller HP, Heinecke A, Borneff M, Kiencke C, Knopf A, Pohl S. Eradication of Actinobacillus actinomycetemcomitans from the oral cavity in adult periodontitis. J Periodontal Res 1998; 33: 49–58. 45Winkel EG, van Winkelhoff AJ, van der Velden U. Additional clinical and microbiological effects of amoxicillin and metronidazole after initial periodontal therapy. J Clin Periodontol 1998; 25: 857–864. 46Van Winkelhoff AJ, Tijhof CJ, de Graaff J. Microbiological and clinical results of metronidazole plus amoxicillin therapy in Actinobacillus actinomycetemcomitans-associated periodontitis. J Periodontol 1992; 63: 52–57. 47Page RC, Eke PI. Case definitions for use in population-based surveillance of periodontitis. J Periodontol 2007; 78: 1387–1399. 48Tonetti MS, Claffey N; European Workshop in Periodontology group C. Advances in the progression of periodontitis and proposal of definitions of a periodontitis case and disease progression for use in risk factor research. Group C consensus report of the 5th European Workshop in Periodontology. J Clin Periodontol 2005; 32(Suppl. 6): 210–213. 49Wærhaug J. Healing of the dento-epithelial junction following subgingival plaque control. II: As observed on extracted teeth. J Periodontol 1978; 49: 119–134. 50Marsh PD, Moter A, Devine DA. Dental plaque biofilms: Communities, conflict and control. Periodontol 2000 2011; 55: 16–35. 51Quirynen M, Bollen CML, Vandekerckhove BNA, Dekeyser C, Papaioannou W, Eyssen H. Full- vs. partial-mouth disinfection in the treatment of periodontal infections: Short-term clinical and microbiological observations. J Dent Res 1995; 74: 1459–1467. 52Teughels W, Dekeyser C, Van Essche M, Quirynen M. One-stage, full-mouth disinfection: Fiction or reality? Periodontol 2000 2009; 50: 39–51. 53Apatzidou DA, Kinane DF. Quadrant root planing versus same-day full-mouth root planing. I. Clinical findings. J Clin Periodontol 2004; 31: 132–140. 54Apatzidou DA, Riggio CF, Kinane DF. Quadrant root planing versus same-day full-mouth root planing. II. Microbiological findings. J Clin Periodontol 2004; 31: 141–148. 55Bollen C M, Mongardini C, Papaioannou W, Van Steenberghe D, Quirynen M. The effect of a one-stage full-mouth disinfection on different intra-oral niches. Clinical and microbiological observations. J Clin Periodontol 1998; 25: 56–66. 56Amid R, Tabeie MB, Kadkhodazadeh M, Mehdizadeh AR, Youssefi N. Local concentration of systemic amoxicillin and metronidazole in healthy and inflamed gingiva: A comparative in vivo study. Drug Metab Drug Interact 2012; 27: 113–118. 57Pähkla ER, Koppel T, Saag M, Pähkla R. Metronidazole concentrations in plasma, saliva, and periodontal pockets in patients with periodontitis. J Clin Periodontol 2005; 32: 163–166. 58Egelberg J. Periodontics, the Scientific Way: Synopses of Human Clinical Studies, 3rd ed. Malmö, Sweden: OdontoScience; 1999: 184. 59Xajigeorgiou C, Sakellari D, Slini T, Baka A, Konstantinidis A. Clinical and microbiological effects of different antimicrobials on generalized aggressive periodontitis. J Clin Periodontol 2006; 33: 254–264. 60Mestnik MJ, Feres M, Figueiredo LC, Duarte PM, Lira EAG, Faveri M. Short-term benefits of the adjunctive use of metronidazole plus amoxicillin in the microbial profile and in the clinical parameters of subjects with generalized aggressive periodontitis. J Clin Periodontol 2010; 37: 353–365. 61Varela VM, Heller D, Silva-Senem MX, Torres MC, Colombo AP, Feres-Filho EJ. Systemic antimicrobials adjunctive to a repeated mechanical and antiseptic therapy for aggressive periodontitis: A 6-month randomized controlled trial. J Periodontol 2011; 82: 1121–1130. 62Baltacioglu E, Aslan M, Sarac Ö, Saybak A, Yuva P. Analysis of clinical results of systemic antimicrobials combined with non-surgical periodontal treatment for generalized aggressive periodontitis. J Can Dent Assoc 2011; 77: b97. 63Guerrero A, Griffiths GS, Nibali L, et al. Adjunctive benefits of systemic amoxicillin and metronidazole in non-surgical treatment of generalized aggressive periodontitis: A randomized placebo-controlled clinical trial. J Clin Periodontol 2005; 32: 1096–1107. 64Matarazzo F, Figueiredo LC, Cruz SE, Faveri M, Feres M. Clinical and microbiological benefits of systemic metronidazole and amoxicillin in treatment of smokers with chronic periodontitis: A randomized placebo-controlled study. J Clin Periodontol 2008; 35: 885–896. 65Winkel EG, van Winkelhoff AJ, Timmerman MF, van der Velden U, Van der Weijden GA. Amoxicillin plus metronidazole in the treatment of adult periodontitis patients. A double-blind placebo-controlled study. J Clin Periodontol 2001; 28: 296–305. 66Oliveira APL, Faveri M, Gursky LC, et al. Effects of periodontal therapy on GCF cytokines in generalized aggressive periodontitis subjects. J Clin Periodontol 2012; 39: 295–302. 67Mestnik MJ, Feres M, Figueiredo LC, et al. The effects of adjunctive metronidazole plus amoxicillin in the treatment of generalized aggressive periodontitis. A 1-year double-blinded, placebo-controlled, randomized clinical trial. J Clin Periodontol 2012; 39: 955–961. 68Casarin RC, Peloso Ribeiro ED, Sallum EA, Nociti FH Jr., Goncalves RB, Casati MZ. The combination of amoxicillin and metronidazole improves clinical and microbiologic results of one-stage, full-mouth, ultrasonic debridement in aggressive periodontitis treatment. J Periodontol 2012; 83: 988–998. 69Rodrigues AS, Lourenção DS, Lima Neto LG, et al. Clinical and microbiologic evaluation, by real-time polymerase chain reaction, of non-surgical treatment of aggressive periodontitis associated with amoxicillin and metronidazole. J Periodontol 2012; 83: 744–752. 70Heller D, Varela VM, Silva-Senem MX, Torres MC, Feres-Filho EJ, Colombo AP. Impact of systemic antimicrobials combined with anti-infective mechanical debridement on the microbiota of generalized aggressive periodontitis: A 6-month RCT. J Clin Periodontol 2011; 38: 355–364. 71Cionca N, Giannopoulou C, Ugolotti G, Mombelli A. Microbiologic testing and outcomes of full-mouth scaling and root planing with or without amoxicillin/metronidazole in chronic periodontitis. J Periodontol 2010; 81: 15–23. 72Cionca N, Giannopoulou C, Ugolotti G, Mombelli A. Amoxicillin and metronidazole as an adjunct to full-mouth scaling and root planing of chronic periodontitis. J Periodontol 2009; 80: 364–371. 73Ribeiro Edel P, Bittencourt S, Zanin IC, et al. Full-mouth ultrasonic debridement associated with amoxicillin and metronidazole in the treatment of severe chronic periodontitis. J Periodontol 2009; 80: 1254–1264. 74Akincibay H, Örsal SÖ, Sengün D, Tözüm TF. Systemic administration of doxycycline versus metronidazole plus amoxicillin in the treatment of localized aggressive periodontitis: A clinical and microbiological study. Quintessence Int 2008; 39(2): e33–e39. 75Johnson JD, Chen R, Lenton PA, Zhang G, Hinrichs JE, Rudney JD. Persistence of extracrevicular bacterial reservoirs after treatment of aggressive periodontitis. J Periodontol 2008; 79: 2305–2312. 76Machtei EE, Younis MN. The use of 2 antibiotic regimens in aggressive periodontitis: Comparison of changes in clinical parameters and gingival crevicular fluid biomarkers. Quintessence Int 2008; 39: 811–819. 77Kaner D, Christian C, Dietrich T, Bernimoulin J-P, Kleber B-M, Friedman A. Timing affects the clinical outcome of adjunctive systemic antibiotic therapy for generalized aggressive periodontitis. J Periodontol 2007; 78: 1201–1208. 78Moeintaghavi A, Talebi-ardakani MR, Haerian-ardakani A, et al. Adjunctive effects of systemic amoxicillin and metronidazole with scaling and root planing: A randomized, placebo-controlled clinical trial. J Contemp Dent Pract 2007; 8: 51–59. 79Moreira RM, Feres-Filho EJ. Comparison between full-mouth scaling and root planing and quadrant-wise basic therapy of aggressive periodontitis. Six-month clinical results. J Periodontol 2007; 78: 1683–1688. 80Guerrero A, Echeverria JJ, Tonetti MS. Incomplete adherence to an adjunctive systemic antibiotic regimen decreases clinical outcomes in generalized aggressive periodontitis patients: A pilot retrospective study. J Clin Periodontol 2007; 34: 897–902. 81Ehmke B, Beikler T, Haubitz I, Karch H, Flemmig TF. Multifactorial assessment of predictors for prevention of periodontal disease progression. Clin Oral Investig 2003; 7: 217–221. Citing Literature Volume85, Issue3March 2014Pages 374-384 ReferencesRelatedInformation
Referência(s)