Technical Guidance on the assessment of the toxigenic potential of Bacillus species used in animal nutrition
2011; Wiley; Volume: 9; Issue: 11 Linguagem: Inglês
10.2903/j.efsa.2011.2445
ISSN1831-4732
Tópico(s)Mycotoxins in Agriculture and Food
ResumoEFSA JournalVolume 9, Issue 11 2445 GuidanceOpen Access Technical Guidance on the assessment of the toxigenic potential of Bacillus species used in animal nutrition EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)Search for more papers by this author EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)Search for more papers by this author First published: 25 November 2011 https://doi.org/10.2903/j.efsa.2011.2445Citations: 13 Panel members: Gabriele Aquilina, Georges Bories, Andrew Chesson, Pier Sandro Cocconcelli, Joop de Knecht, Noël Albert Dierick, Mikolaj Antoni Gralak, Jürgen Gropp, Ingrid Halle, Christer Hogstrand, Reinhard Kroker, Lubomir Leng, Secundino Lopez Puente, Anne-Katrine Lundebye Haldorsen, Alberto Mantovani, Giovanna Martelli, Miklós Mézes, Derek Renshaw, Maria Saarela, Kristen Sejrsen and Johannes Westendorf Correspondence: feedap@efsa.europa.eu Acknowledgement: The Panel wishes to thank the members of the Working Group on Micro-organisms including Atte von Wright, Per Einar Granum and Christophe Nguyen-thé for the preparatory work on this scientific opinion. Adoption date: 15 November 2011 Published date: 25 November 2011 Question number: EFSA-Q-2009-00973 On request from: EFSA AboutPDF ToolsExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Abstract Applicants seeking regulatory approval for strains of Bacillus species have relied for guidance on how to assess any toxigenic potential on a SCAN opinion published in 2000. Subsequent to this opinion there have been significant developments in the knowledge of the nature of the toxins found in Bacillus species and their prevalence. In addition, a number of Bacillus species to which the SCAN opinion would have applied have now been transferred to other genera (Geobacillus, Aneurinibacillus and Paenibacillus). In view of the need to update the guidance contained in the SCAN opinion, the FEEDAP Panel takes the opportunity to adopt the revision as part of its technical guidance. The SCAN guidance took as its basis that toxins produced by species other than members of the B. cereus taxonomic group would have sufficiently similar properties to the known B. cereus toxins to be detected by the methods developed for the B. cereus group. It now seems unlikely that B. cereus-like enterotoxins are produced in species other than the B. cereus group. Any toxigenic potential in other species appears far more likely to arise from the production of surfactins. A test for haemolysis coupled with PCR detection of non-ribosomal peptide synthase genes seems adequate to identify surfactin-positive strains. 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