Portal de Periódicos da CAPES

Microglandular adenosis of the breast

1983; Lippincott Williams & Wilkins; Volume: 7; Issue: 8 Linguagem: Inglês

10.1097/00000478-198312000-00002

1532-0979

F. A. Tavassoli, H. J. Norris,

Breast Implant and Reconstruction

The clinical and pathologic features of 11 examples of microglandular adenosis of the breast are presented. Microglandular adenosis is a rare, benign lesion that is easily confused with carcinoma. It is characterized by a concentrated proliferation of round glands with open lumens in a densely homogeneous stroma that clearly delineates microglandular adenosis from the adjacent uninvolved breast. The glands are lined by a single layer of cells with distinctly vacuolated or granular cytoplasm. Ultrastructurally, the single layer of epithelial cells lacks cytoplasmic protrusions and is surrounded by a thick multilayered basement membrane. Light- and electronmicroscopic features that help distinguish microglandular adenosis from well-differentiated (tubular) carcinoma and sclerosing adenosis, entities with which it is easily confused, are discussed.