Portal de Periódicos da CAPES

VP15.18: Influence of intra‐amniotic infection and inflammation on the fetal cardiac structure

2020; Wiley; Volume: 56; Issue: S1 Linguagem: Inglês

10.1002/uog.22562

1469-0705

C. Murillo Bravo, M. Larroya Sola, F. Crispi, O. Gómez, I. Soveral, Laura García‐Otero, Claudia Orden Rueda, Silvia Ferrero, Laia Grau, Montse Palacio, Teresa Cobo,

Pregnancy and preeclampsia studies

To assess the influence of intraamniotic infection and/or inflammation (IAI) on the fetal cardiac structure in preterm labour (PTL) and/or preterm prelabour rupture of membranes (PPROM). Prospective cohort study (2018-2019) including singleton pregnancies with PTL and/or PPROM with an amniocentesis at admission; and asymptomatic (non-exposed) women. We compared women with PTL and/or PPROM with IAI (n = 18), without IAI (n = 22) and a non-exposed group (n = 20). IAI was defined by a positive culture and/or high levels of amniotic fluid Interleukin-6. Cardiothoracic area and myocardial thicknesses were evaluated by fetal echocardiography in end-diastole. Myocardial thicknesses were assesed by M-mode. Results were adjusted for gestational age, estimated fetal weight and fetal sex. Myocardial thicknesses were adjusted also by cardiac area. Patterns of ventricular hypertrophy were assessed by relative wall thickness using M-mode. We did not find any significant differences in epidemiological characteristics (maternal age, BMI, smoking habit, ethnicity, fetal gender, gestational age and estimated fetal weight at ultrasound) between groups. Results on cardiothoracic area and M-mode myocardial thicknesses are shown in table 1. The data suggest a concentric myocardial hypertrophy in the groups with PTL and/or PPROM compared to the control group. These changes are more pronounced in fetuses with IAI. More studies are needed to assess these fetal changes and their possible postnatal impact, although these findings are consistent with the published data in premature infants.