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Recurrent chromosomal abnormalities in hepatocellular carcinoma detected by comparative genomic hybridization

1997; Wiley; Volume: 18; Issue: 1 Linguagem: Inglês

10.1002/(sici)1098-2264(199701)18

1098-2264

Agnès Marchio, Mounira Meddeb, Pascal Pineau, Gisèle Danglot, Pierre Tiollais, Alain Bernheim, Anne Dejean,

Liver Disease Diagnosis and Treatment

Genes, Chromosomes and CancerVolume 18, Issue 1 p. 59-65 Research Article Recurrent chromosomal abnormalities in hepatocellular carcinoma detected by comparative genomic hybridization Agnès Marchio, Corresponding Author Agnès Marchio Unité de Recombinaison et Expression Génétique, INSERM U163, Institut Pasteur, Paris, FranceUnité de Recombinaison et Expression Génétique, INSERM U163, Institut Pasteur, 75724 Paris cedex 15, FranceSearch for more papers by this authorMounira Meddeb, Mounira Meddeb Laboratoire de Cytogénétique et de Génétique Oncologiques (URA 1967 CNRS), Institut Gustave Roussy, Villejuif, FranceSearch for more papers by this authorPascal Pineau, Pascal Pineau Unité de Recombinaison et Expression Génétique, INSERM U163, Institut Pasteur, Paris, FranceSearch for more papers by this authorGisèle Danglot, Gisèle Danglot Laboratoire de Cytogénétique et de Génétique Oncologiques (URA 1967 CNRS), Institut Gustave Roussy, Villejuif, FranceSearch for more papers by this authorPierre Tiollais, Pierre Tiollais Unité de Recombinaison et Expression Génétique, INSERM U163, Institut Pasteur, Paris, FranceSearch for more papers by this authorAlain Bernheim, Alain Bernheim Laboratoire de Cytogénétique et de Génétique Oncologiques (URA 1967 CNRS), Institut Gustave Roussy, Villejuif, FranceSearch for more papers by this authorAnne Dejean, Anne Dejean Unité de Recombinaison et Expression Génétique, INSERM U163, Institut Pasteur, Paris, FranceSearch for more papers by this author Agnès Marchio, Corresponding Author Agnès Marchio Unité de Recombinaison et Expression Génétique, INSERM U163, Institut Pasteur, Paris, FranceUnité de Recombinaison et Expression Génétique, INSERM U163, Institut Pasteur, 75724 Paris cedex 15, FranceSearch for more papers by this authorMounira Meddeb, Mounira Meddeb Laboratoire de Cytogénétique et de Génétique Oncologiques (URA 1967 CNRS), Institut Gustave Roussy, Villejuif, FranceSearch for more papers by this authorPascal Pineau, Pascal Pineau Unité de Recombinaison et Expression Génétique, INSERM U163, Institut Pasteur, Paris, FranceSearch for more papers by this authorGisèle Danglot, Gisèle Danglot Laboratoire de Cytogénétique et de Génétique Oncologiques (URA 1967 CNRS), Institut Gustave Roussy, Villejuif, FranceSearch for more papers by this authorPierre Tiollais, Pierre Tiollais Unité de Recombinaison et Expression Génétique, INSERM U163, Institut Pasteur, Paris, FranceSearch for more papers by this authorAlain Bernheim, Alain Bernheim Laboratoire de Cytogénétique et de Génétique Oncologiques (URA 1967 CNRS), Institut Gustave Roussy, Villejuif, FranceSearch for more papers by this authorAnne Dejean, Anne Dejean Unité de Recombinaison et Expression Génétique, INSERM U163, Institut Pasteur, Paris, FranceSearch for more papers by this author First published: 07 December 1998 https://doi.org/10.1002/(SICI)1098-2264(199701)18:1 3.0.CO;2-0Citations: 210AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Abstract Comparative genomic hybridization (CGH) was used to evaluate and map genomic aberrations in 50 hepatocellular carcinomas (HCCs) from patients chronically infected with hepatitis B virus (HBV). CGH clearly detected nonrandom genomic imbalances. Losses were most prevalent on chromosome regions 4q (70%), 8p (65%), 16q (54%), 17p (51%), 13q and 6q (37% each), and 1p (30%). The most frequent gains occurred on 8q (60%), 1q (58%), and 6p and 17q (33% each). In a few cases, sequence amplifications were detected that were mapped to bands 11q12, 12p11, 14q12, and 19q13.1. This study represents the first analysis of primary liver cancers by CGH, and it confirms the presence of previously known chromosomal aberrations in HCC and highlights new quantitative abnormalities and sequence amplifications. These findings should lead to the characterization of new loci involved in liver cancer pathogenesis. Genes Chromosom. Cancer 18:59–65, 1997. © 1997 Wiley-Liss, Inc. Citing Literature Volume18, Issue1January 1997Pages 59-65 RelatedInformation