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Hydrogen-transfer reduction of carbonyl compounds promoted by nickel nanoparticles

2007; Elsevier BV; Volume: 64; Issue: 8 Linguagem: Inglês

10.1016/j.tet.2007.11.093

1464-5416

Francisco Alonso, Paola Riente, Miguel Yus,

Nanomaterials for catalytic reactions

Nickel(0) nanoparticles, generated from nickel(II) chloride, lithium powder and a catalytic amount of 4,4-di-tert-butylbiphenyl (DTBB) in THF at room temperature, have been found to promote the reduction of a variety of ketones and aldehydes by transfer hydrogenation using isopropanol as the hydrogen donor. The nickel nanoparticles were characterised and could be re-utilised with a good performance in the absence of a base. A mechanistic study demonstrates that the reaction proceeds through a dihydride-type mechanism.