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Abstracts of the Second International Congress on Fetal MRI

2008; Wiley; Volume: 31; Issue: 5 Linguagem: Inglês

10.1002/uog.5338

1469-0705

Csilla Balássy, Gregor Kasprian, B Csapó, P. C. Brugger, Daniela Prayer, D. Blondin, Mathias Cohnen, U Ödder, R Hammer, M Messing-J Ünger, Jörg Schaper, Elena Bravo, Maida P. Galvez, Cecilia Okuma, Rodrigo Rivera, Gabriel Sordo, Lautaro Badilla, E. Hafner,

Advanced MRI Techniques and Applications

Purpose: To study lung development in congenital diaphragmatic hernia (CDH) using changes in signal intensity (SI) ratios and lung volumes.Methods: 16 fetuses (22-27 weeks of gestation) were examined with a 1.5 Tesla unit.Mean SIs for lungs, liver were assessed on T1-and T2-weighted sequences, then lung/liver signal intensity ratios (LLSIR) were calculated, and together with lung volumes were compared to an age matched control group of 146 fetuses using t-test and U-test.Neonatal outcomes were also assessed and correlated with the changes of SIRs and lung volumes.Results: Mean SIs and LLSIRs were significantly higher in both lungs on T1-weighted images, compared to the normal group (p < 0.001 and (p = 0.029, respectively).On T2 w imaging mean SIs were increased in both lungs compared to the age matched controls (p < 0.001), but not the LLSIR.As expected, total lung volumes were significantly smaller in the CDH group than in the controls (p < 0.001).Outcomes correlated significantly with total lung volumes, but not with signal intensity changes in the lungs. Conclusion:The significantly greater increase of SIs and LLSIR T1w in CDH can be explained by the relatively higher proportions of lung parenchyma, compared to normal fetuses.The SI increase on T2-weighted images is presumably caused by the accumulation of concentrated alveolar fluid with higher protein content.