Shiga toxins
2001; Elsevier BV; Volume: 39; Issue: 11 Linguagem: Inglês
10.1016/s0041-0101(01)00150-7
ISSN1879-3150
Autores Tópico(s)Toxin Mechanisms and Immunotoxins
ResumoShiga toxin and Shiga-like toxins belong to the group of protein toxins which have a moiety that binds to the cell surface and another enzymatically active moiety that after entry into the cytosol inhibits protein synthesis enzymatically. The toxins can also cause apoptosis by mechanisms that may be different from the effect on the protein synthesis machinery. Shigella dysenteriae, some strains of Escherichia coli as well as other bacteria can secrete such toxins which cause serious complications during infections. An increasing knowledge about the toxins and their interactions with cells is important both for treatment of disease, and for elucidation of pathways of intracellular transport.
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