Striatonigral Degeneration
2010; Elsevier BV; Linguagem: Inglês
10.1016/b978-0-12-374105-9.00077-0
Autores Tópico(s)Genetic Neurodegenerative Diseases
ResumoStriatonigral degeneration (SND), a form of multiple system atrophy (MSA), is a sporadic neurodegenerative disease with adult onset. In its prototypic form, it is typically characterized by parkinsonism that is less responsive to dopaminergic drugs than is Parkinson's disease, a very distinctive anterocollic posture, and pyramidal signs. Autonomic failure and cerebellar signs are less marked in SND than in other forms of MSA. Absolute diagnosis depends on neuropathological findings. There are some characteristic MRI findings of SND; however, these are not specific and can only be used as supportive evidence. Electromyography (EMG) and autonomic testing are other ancillary tests that might be helpful. Treatment for SND is symptomatic, and may include a trial of levodopa, amantadine, or dopamine agonists.
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