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Impact of SARS-CoV-2 viral load and duration of symptoms before hospital admission on the mortality of hospitalized COVID-19 patients

2022; Springer Science+Business Media; Volume: 50; Issue: 5 Linguagem: Inglês

10.1007/s15010-022-01833-8

1439-0973

Verónica Rico, Mariana Fernández, Juan Carlos Hurtado, María Ángeles Marcos, Celia Cardozo, Laia Albiach, Daiana Agüero, Juan Ambrosioni, Marta Bodro, Mariana Chumbita, Lorena de la Mora, Nicole García-Pouton, Ana González-Cordón, Gerard Dueñas, Marta Hernández‐Meneses, Alexy Inciarte, Montse Laguno, Lorna Leal, Irene Macaya, Miguel J. Martínez, Genoveva Cuesta, Fernanda Meira, Laura Morata, Pedro Puerta‐Alcalde, John Rojas, Berta Torres, Pedro Castro, José Muñóz, Josep Mensa, José Antonio Martínez, Gemma Sanjuan, Jordi Vilà, Felipe García, Carolina García‐Vidal, Álex Soriano, José Luís Blanco, Josep Mallolas, Estebán Martínez, Miguel J. Martínez, Josep M. Miró, Antonio Moreno, Ana del Rı́o, M. Larroya Sola, Manuel Muñoz‐Torres, Ainoa Ugarte, A. Cozar-Lladó, Laura Linares, Adrián Téllez, Sara Fernández, José M. Nicolás, D. Campubri, M. T. de Alba, M. Fernandez, Esther Jaén Ferrer, B. Grau, Helena Martí-Soler, Magdalena Muelas‐Fernandez, María‐Jesús Pinazo, Natàlia Rodríguez, M. Roldan, Carme Subirá, Isabel Vera, Neely Williams, Alex Almuedo-Riera, Anna Aldea, Miguel Camafort, Jorge Calvo, Abelardo Capdevila, Francesc Cardellach, Irene Carbonell, Emmanuel Coloma, Alberto Foncillas, Ramón Estruch, M. Feliu, Joaquim Fernández‐Solà, Irene Fuertes, Cristina Gabara, Ignacio Grafiá, A. Ladino, R. López-Alfaro, Alfonso López‐Soto, Ferrán Masanés, Arthur J. Matas, Mireia Navarro, Javier Marco‐Hernández, Lucas San Miguel, José C. Milisenda, Pedro R. Moreno, José Naval-Álvarez, David Nicolás, H.K. Oberoi, Joan Padrosa, Sergio Prieto‐González, Martina Pellicé, J. G. Ribot, Olga Rodríguez-Núñez, Emilio Sacanella, Ferran Seguí, Cristina Sierra, Adrià Tomé, Manuel Muñoz‐Torres, Helena Ventosa, Carles Zamora, Manuel Almela, Míriam J. Álvarez, J. Bosch, Josep Costa, Genoveva Cuesta, Berta Fidalgo, Júlia de Oliveira Gonzalez, Francesc Marco, Sofía Narváez, Cristina Pitart, Elisa Rubio, Ander Vergara, María Eugenia Valls, Yuliya Zboromyrska, Climent Casals‐Pascual, Mar Mosquera, E. López, Montse Tuset,

COVID-19 Clinical Research Studies

Assess the impact of viral load estimated by cycle threshold (Ct) of reverse transcription real time-polymerase chain reaction (rRT-PCR) and the days from symptoms onset on mortality in hospitalized patients with COVID19.Retrospective observational study of 782 patients with a positive rRT-PCR from a nasopharyngeal swab was performed within the first 24 h from admission. Demographic data, clinical manifestations and laboratory parameters were collected. Uni- and multivariate analyses were performed to identify factors associated with mortality at 60 days.Ct was divided into three groups and the mortality rate decreased from 27.3 to 20.7% and 9.8% for Ct values of ≤ 20, 21-25 and > 25, respectively (P = 0.0001). The multivariate analysis identified as predictors of mortality, a Ct value < 20 (OR 3.13, CI 95% 1.38-7.10), between 21-25 (OR 2.47, CI 95% 1.32-4.64) with respect to a Ct value > 25. Days from symptoms onset is a variable associated with mortality as well (DSOA) ≤ 6 (OR 1.86, CI 95% 1.00-3.46), among other factors. Patients requiring hospital admission within 6 DSOA with a Ct value ≤ 25 had the highest mortality rate (28%).The inclusion of Ct values and DSOA in the characterization of study populations could be a useful tool to evaluate the efficacy of antivirals.