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Effects of Baru Almond Oil (Dipteryx alata Vog.) Treatment on Thrombotic Processes, Platelet Aggregation, and Vascular Function in Aorta Arteries

2022; Multidisciplinary Digital Publishing Institute; Volume: 14; Issue: 10 Linguagem: Inglês

10.3390/nu14102098

2072-6643

Cristiane Cosmo Silva-Luis, José Luiz de Brito Alves, Júlio César Pinheiro Lúcio de Oliveira, José Luís, Islania Giselia Albuquerque Araújo, Josean Fechine Tavares, Yuri Mangueira do Nascimento, Lorena Soares Bezerra, Fátima de Lourdes Assunção Araújo de Azevedo, Marianna Vieira Sobral, Vivianne Mendes Mangueira, Isac Almeida de Medeiros, Robson Cavalcante Veras,

Antioxidant Activity and Oxidative Stress

Background: This study assessed the effects of Baru (Dipteryx alata Vog.) almond oil supplementation on vascular function, platelet aggregation, and thrombus formation in aorta arteries of Wistar rats. Methods: Male Wistar rats were allocated into three groups. The control group (n = 6), a Baru group receiving Baru almond oil at 7.2 mL/kg/day (BG 7.2 mL/kg, n = 6), and (iii) a Baru group receiving Baru almond oil at 14.4 mL/kg/day (BG 14.4 mL/kg, n = 6). Baru oil was administered for ten days. Platelet aggregation, thrombus formation, vascular function, and reactive oxygen species production were evaluated at the end of treatment. Results: Baru oil supplementation reduced platelet aggregation (p < 0.05) and the production of the superoxide anion radical in platelets (p < 0.05). Additionally, Baru oil supplementation exerted an antithrombotic effect (p < 0.05) and improved the vascular function of aorta arteries (p < 0.05). Conclusion: The findings showed that Baru oil reduced platelet aggregation, reactive oxygen species production, and improved vascular function, suggesting it to be a functional oil with great potential to act as a novel product for preventing and treating cardiovascular disease.