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Acinetobacter baumannii and Its Relationship to Carbapenem Resistance: A Meta-Analysis

2022; Volume: 1; Issue: 2 Linguagem: Inglês

10.3390/bacteria1020010

2674-1334

Diego Lucas Neres Rodrigues, Francielly Morais Rodrigues da Costa, Wanderson Marques da Silva, Flávia Figueira Aburjaile, Vasco Azevedo,

Antibiotic Use and Resistance

Infections by antibiotic-resistant bacteria are a significant and complex global health issue. In this context, Acinetobacter baumannii is particularly important because of its ability to withstand treatments by β-lactams, such as carbapenem. The objective of this work was to investigate, through systematic analysis and meta-analysis, the chance of resistance to carbapenem in A. baumannii strains. For this, a search was conducted for the PubMed and Cochrane databases based on the keywords: “Acinetobacter baumannii” AND “beta-lactam” OR “penicillin” OR “cephalosporin” OR “cephamycin” OR “carbapenem” OR “monobactam”. The initial search resulted in a total of 90,475 articles. It was filtered based on eligibility criteria, and eight articles were selected for analysis. An odds ratio value equivalent to 3.55 was obtained, indicating a high chance of resistance to the carbapenem of strains of the species. Therefore, it is supposed that A. baumannii infection cases have a high probability of not responding adequately to treatments based on carbapenem.