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Vaccination against SARS-CoV-2 protects from morbidity, mortality and sequelae from COVID19 in patients with cancer

2022; Elsevier BV; Volume: 171; Linguagem: Inglês

10.1016/j.ejca.2022.04.036

1879-0852

David J. Pinato, Daniela Ferrante, Juan Aguilar‐Company, Mark Bower, Ramón Salazar, Oriol Mirallas, Anna Sureda, Alexia Bertuzzi, Joan Brunet, Matteo Lambertini, Clara Maluquer, Paolo Pedrazzoli, Federica Biello, Alvin Lee, Christopher C.T. Sng, Raquel Liñan, Sabrina Rossi, M. Carmen Carmona-García, Rachel Sharkey, Simeón Eremiev, Gianpiero Rizzo, Hamish DC. Bain, Tamara Yu, Claudia Andrea Cruz, Marta Perachino, Nadia Saoudi, Roser Fort‐Culillas, Kris Doonga, María Laura Fox, Elisa Roldán, Federica Zoratto, Gianluca Gaïdano, Isabel Ruiz‐Camps, Riccardo Bruna, Andrea Patriarca, Marianne Shawe‐Taylor, Vittorio Fusco, Clara Martínez-Vila, Rossana Berardi, Marco Filetti, Francesca Mazzoni, Armando Santoro, Sara Delfanti, Alessandro Parisi, Paola Queirolo, Avinash Aujayeb, Lorenza Rimassa, Aleix Prat, Josep Tabernero, Alessandra Gennari, Alessio Cortellini, David J. Pinato, Joanne Evans, Judith Swallow, Alessio Cortellini, Georgina Hanbury, Chris Chung, Meera Patel, Gino Dettorre, Diego Ottaviani, Amani Chowdhury, Alvin Lee, Christopher C.T. Sng, Tamara Yu, Marianne Shawe‐Taylor, Hamish DC. Bain, Alasdair Sinclair, Lauren Cooper, Lucy Rogers, Katherine Belessiotis, Cian Murphy, Samira Bawany, Saira Khalique, Ramis Andaleeb, Mark Bower, Alessia Dalla Pria, Rachel Sharkey, Thomas Newsom-Davis, Saorise Dolly, Ailsa Sita-Lumsde, Eleanor Apthorp, Eleanor Jones, Mieke Van Hemelrijck, Charlotte Moss, Beth Russell, Eleanor Apthorp, Nikolaos Diamantis, Uma Mukherjee, Sarah Townsend, Amanda Jackson, Angela Loizidou, Martine Piccart, Aleix Prat, Claudia Andrea Cruz, Roxana Reyes, Elia Seguí, Javier Marco‐Hernández, Margarita Viladot, Josep Tabernero, Juan Aguilar‐Company, Isabel Ruiz‐Camps, María Laura Fox, David Garcia Illescas, Nadia Saoudi, Oriol Mirallas, Elisa Roldán, Joan Brunet, MCarmen Carmona Garcia, Robert Fort-Culillas, Raquel Liñan, Nadia Harbeck, Rachel Wuerstlein, Franziska Henze, Sven� Mahner, Ricard Mesı́a, Eudald Felip, Andrea Plaja, Marc Cucurull, Ramón Salazar, Anna Sureda, Clara Maluquer, Alessandra Gennari, Federica Biello, Francesca D’Avanzo, Gianluca Gaïdano, Riccardo Bruna, Andrea Patriarca, Daniela Ferrante, Lorenza Scotti, Marco Krengly, Paolo Pedrazzoli, Gianpiero Rizzo, Alexia Bertuzzi, Sabrina Rossi, Andrea Marrari, Armando Santoro, Lorenza Rimassa, Federica Grosso, Vittorio Fusco, Sara Delfanti, Antonio Maconi, Marta Betti, Bruno Vincenzi, Giuseppe Tonini, Alberto Zambelli, Carlo Tondini, Vittoria Fotia, Lorenzo Chiudinelli, Michela Franchi, Michela Libertini, Rossella Bertulli, Salvatore Provenzano, Daniele Generali, Salvatore Grisanti, Alice Baggi, Valeria Tovazzi, Corrado Ficorella, Giampiero Porzio, Alessandro Parisi, Paola Queirolo, Maristella Saponara, Raffaele Giusti, Marco Filetti, Francesca Mazzoni, Federica Zoratto, Marco Tucci, Rossana Berardi, Luca Cantini, Francesco Paoloni, Annalisa Guida, Sergio Bracarda, Clara Martínez-Vila, María Iglesias, Ana Sánchez, Matteo Lambertini, Marta Perachino, Fanny Pommeret, Émeline Colomba,

COVID-19 Clinical Research Studies

BackgroundAlthough SARS-CoV-2 vaccines immunogenicity in patients with cancer has been investigated, whether they can significantly improve the severity of COVID-19 in this specific population is undefined.MethodsCapitalizing on OnCovid (NCT04393974) registry data we reported COVID-19 mortality and proxies of COVID-19 morbidity, including post-COVID-19 outcomes, according to the vaccination status of the included patients.Results2090 eligible patients diagnosed with COVID-19 between 02/2020 and 11/2021 were included, of whom 1930 (92.3%) unvaccinated, 91 (4.4%) fully vaccinated and 69 (3.3%) partially vaccinated. With the exception of a higher prevalence of patients from the UK (p = 0.0003) and receiving systemic anticancer therapy at COVID-19 diagnosis (p = 0.0082) among fully vaccinated patients, no demographics/oncological features were associated with vaccination status. The 14-days case fatality rate (CFR) (5.5% vs 20.7%, p = 0.0004) and the 28-days CFR (13.2% vs 27.4%, p = 0.0028) demonstrated a significant improvement for fully vaccinated patients in comparison with unvaccinated patients. The receipt of prior full vaccination was also associated with reduced symptomatic COVID-19 (79.1% vs 88.5%, p = 0.0070), need of COVID-19 oriented therapy (34.9% vs 63.2%, p < 0.0001), complications from COVID-19 (28.6% vs 39.4%, p = 0.0379), hospitalizations due to COVID-19 (42.2% vs 52.5%, p = 0.0007) and oxygen therapy requirement (35.7% vs 52%, p = 0.0036). Following Inverse Probability Treatment Weighting (IPTW) procedure no statistically significant difference according to the vaccination status was confirmed; however, all COVID-19 related outcomes were concordantly in favour of full vaccination. Among the 1228 (58.8%) patients who underwent a formal reassessment at participating centres after COVID-19 resolution, fully vaccinated patients experienced less sequelae than unvaccinated patients (6.7% vs 17.2%, p = 0.0320).ConclusionsThis analysis provides initial evidence in support of the beneficial effect of SARS-CoV-2 vaccines against morbidity and mortality from COVID-19 in patients with cancer.