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A core group of structurally similar HLA-DPB1 alleles drives permissiveness after hematopoietic cell transplantation

2022; Elsevier BV; Volume: 140; Issue: 6 Linguagem: Inglês

10.1182/blood.2022015708

1528-0020

Esteban Arrieta‐Bolaños, Pietro Crivello, Meilun He, Tao Wang, Shahinaz M. Gadalla, Sophie Paczesny, Steven G. E. Marsh, Stephanie J. Lee, Stephen R. Spellman, Yung‐Tsi Bolon, Katharina Fleischhauer,

T-cell and B-cell Immunology

Letter to Blood| August 11, 2022 A core group of structurally similar HLA-DPB1 alleles drives permissiveness after hematopoietic cell transplantation Esteban Arrieta-Bolaños, Esteban Arrieta-Bolaños Institute for Experimental Cellular Therapy, University Hospital Essen, Essen, Germany;German Cancer Consortium (DKTK), partner site Essen/Düsseldorf, Essen, Germany; https://orcid.org/0000-0002-3696-5803 Search for other works by this author on: This Site PubMed Google Scholar Pietro Crivello, Pietro Crivello Institute for Experimental Cellular Therapy, University Hospital Essen, Essen, Germany; https://orcid.org/0000-0001-9668-5013 Search for other works by this author on: This Site PubMed Google Scholar Meilun He, Meilun He CIBMTR (Center for International Blood and Marrow Transplant Research), National Marrow Donor Program/Be The Match, Minneapolis, MN; Search for other works by this author on: This Site PubMed Google Scholar Tao Wang, Tao Wang Division of Biostatistics, Institute for Health and Equity, Medical College of Wisconsin, Milwaukee, WI;CIBMTR (Center for International Blood and Marrow Transplant Research), Department of Medicine, Medical College of Wisconsin, Milwaukee, WI; https://orcid.org/0000-0002-2596-6843 Search for other works by this author on: This Site PubMed Google Scholar Shahinaz M. Gadalla, Shahinaz M. Gadalla Division of Cancer Epidemiology & Genetics, National Institutes of Health-National Cancer Institute Clinical Genetics Branch, Rockville, MD; https://orcid.org/0000-0002-3255-8143 Search for other works by this author on: This Site PubMed Google Scholar Sophie Paczesny, Sophie Paczesny Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC; https://orcid.org/0000-0001-5571-2775 Search for other works by this author on: This Site PubMed Google Scholar Steven G. E. Marsh, Steven G. E. Marsh Anthony Nolan Research Institute, London, United Kingdom;UCL Cancer Institute, Royal Free Campus, London, United Kingdom; Search for other works by this author on: This Site PubMed Google Scholar Stephanie J. Lee, Stephanie J. Lee CIBMTR (Center for International Blood and Marrow Transplant Research), Medical College of Wisconsin, Milwaukee, WI; andClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA https://orcid.org/0000-0003-2600-6390 Search for other works by this author on: This Site PubMed Google Scholar Stephen R. Spellman, Stephen R. Spellman CIBMTR (Center for International Blood and Marrow Transplant Research), National Marrow Donor Program/Be The Match, Minneapolis, MN; Search for other works by this author on: This Site PubMed Google Scholar Yung-Tsi Bolon, Yung-Tsi Bolon CIBMTR (Center for International Blood and Marrow Transplant Research), National Marrow Donor Program/Be The Match, Minneapolis, MN; https://orcid.org/0000-0001-9414-6120 Search for other works by this author on: This Site PubMed Google Scholar Katharina Fleischhauer Katharina Fleischhauer Institute for Experimental Cellular Therapy, University Hospital Essen, Essen, Germany;German Cancer Consortium (DKTK), partner site Essen/Düsseldorf, Essen, Germany; https://orcid.org/0000-0002-5827-8000 Search for other works by this author on: This Site PubMed Google Scholar Blood (2022) 140 (6): 659–663. https://doi.org/10.1182/blood.2022015708 Article history Submitted: January 27, 2022 Accepted: May 12, 2022 First Edition: May 24, 2022 Share Icon Share Facebook Twitter LinkedIn MailTo Tools Icon Tools Request Permissions Cite Icon Cite Search Site Citation Esteban Arrieta-Bolaños, Pietro Crivello, Meilun He, Tao Wang, Shahinaz M. Gadalla, Sophie Paczesny, Steven G. E. Marsh, Stephanie J. Lee, Stephen R. Spellman, Yung-Tsi Bolon, Katharina Fleischhauer; A core group of structurally similar HLA-DPB1 alleles drives permissiveness after hematopoietic cell transplantation. Blood 2022; 140 (6): 659–663. doi: https://doi.org/10.1182/blood.2022015708 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBlood Search Subjects: Immunobiology and Immunotherapy, Transplantation TO THE EDITOR: Clinically tolerable, permissive HLA-DPB1 mismatches defined by the T-cell epitope (TCE) model improve the selection of unrelated donors in allogeneic hematopoietic cell transplantation (HCT).1 Nonpermissive mismatches across TCE groups have been shown to be associated with stronger alloreactive responses and worse clinical outcomes compared with permissive mismatches within the same TCE group.2-4 We have recently demonstrated that the biological basis of permissiveness is associated with the peptide repertoires (immunopeptidomes) presented by these molecules, which play a central role in determining the strength and T-cell receptor diversity of the alloreactive responses that they elicit.5 Less immunogenic HLA-DP molecules have similar bound peptide motifs6,7 and overlapping immunopeptidomes.5 Although the role of structural similarity and overlapping immunopeptidomes in vitro is clear,5 their relevance for alloresponses in vivo is still unknown. 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Haplo-PtCy: adjusting the HLA barrier. Blood. 2022;139(10):1431-1433.Google ScholarCrossrefSearch ADS PubMed © 2022 by The American Society of Hematology2022 © 2022 by The American Society of Hematology2022 You do not currently have access to this content. Sign in via your Institution