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Clinical features and management of human monkeypox: a retrospective observational study in the UK

2022; Elsevier BV; Volume: 22; Issue: 8 Linguagem: Inglês

10.1016/s1473-3099(22)00228-6

1474-4457

Hugh Adler, Susan Gould, Paul Hine, Luke B. Snell, Waison Wong, Catherine Houlihan, Jane C Osborne, Tommy Rampling, Mike Beadsworth, C.J. Duncan, Jake Dunning, Tom Fletcher, Ewan Hunter, Michael Jacobs, Saye Khoo, William Newsholme, David A. Porter, Robert Porter, Libuše Ratcliffe, Matthias L. Schmid, Malcolm G. Semple, Anne Tunbridge, Tom Wingfield, Nicholas M. Price, Michael Abouyannis, Asma Al-Balushi, Stephen Aston, R.C. Ball, Nicholas J. Beeching, Thomas J Blanchard, Ffion Carlin, Geraint Davies, Angela Gillespie, Scott Rory Hicks, M Hoyle, Chinenye Ilozue, Luke Mair, Suzanne Marshall, Anne Neary, Emmanuel Nsutebu, Samantha Parker, Hannah Ryan, Lance Turtle, Christopher Smith, J.J. van Aartsen, Naomi F. Walker, Stephen Woolley, Anu Chawla, Ian R. Hart, Anna Smielewska, Elizabeth Joekes, Cathryn Benson, Cheryl Brindley, Urmi Das, Chin K Eyton-Chong, Claire Gnanalingham, Clare Halfhide, Beatriz Larrú, Sarah Mayell, Joanna McBride, Claire Oliver, Princy Paul, Andrew Riordan, Lekha Sridhar, Megan Storey, A Abdul, Jennifer Abrahamsen, Breda Athan, Sanjay Bhagani, Colin Brown, Oliver Carpenter, Ian Cropley, Kerrie Frost, Susan Hopkins, Jessica Joyce, Lucy Lamb, Adrian Lyons, Tabitha Mahungu, Stephen Mepham, Edina Mukwaira, Alison Rodger, Caroline Taylor, Simon Warren, Alan Williams, D Levitt, D. C. Allen, Jill Dixon, Adam Evans, Pauline McNicholas, Brendan Payne, Ashley Price, Uli Schwab, Allison Sykes, Yusri Taha, Margaret Ward, Marieke Emonts, Stephen Owens, Alina Botgros, Sam Douthwaite, Anna Goodman, Akish Luintel, Eithne MacMahon, Gaia Nebbia, Geraldine O’Hara, J. D. Parsons, Ashwin Sen, Daniel E. Stevenson, Tadgh Sullivan, Usman Taj, Claire van Nipsen tot Pannerden, Helen Winslow, Ewa Zatyka, Ekene Alozie-Otuka, Csaba Beviz, Yusupha Ceesay, Latchmin Gargee, Morloh Kabia, Hannah Mitchell, Shona Perkins, Mingaile Sasson, Kamal Sehmbey, Federico Tabios, Neil Wigglesworth, Emma Aarons, Tim Brooks, Matthew Dryden, Jenna Furneaux, Barry Gibney, Jennifer Small, Elizabeth J Truelove, Clare E Warrell, Richard Firth, Gemma Hobson, Christopher Johnson, Alison Dewynter, Sebastian Nixon, Oliver Spence, Joachim J. Bugert, Dennis E. Hruby,

Bacillus and Francisella bacterial research

Cases of human monkeypox are rarely seen outside of west and central Africa. There are few data regarding viral kinetics or the duration of viral shedding and no licensed treatments. Two oral drugs, brincidofovir and tecovirimat, have been approved for treatment of smallpox and have demonstrated efficacy against monkeypox in animals. Our aim was to describe the longitudinal clinical course of monkeypox in a high-income setting, coupled with viral dynamics, and any adverse events related to novel antiviral therapies.