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Serum polyethylene glycol-specific IgE and IgG in patients with hypersensitivity to COVID-19 mRNA vaccines

2022; Elsevier BV; Volume: 71; Issue: 4 Linguagem: Inglês

10.1016/j.alit.2022.05.007

1440-1592

Mariko Mouri, Mitsuru Imamura, Shotaro Suzuki, Tatsuya Kawasaki, Yoshiki ISHIZAKI, Keiichi Sakurai, Hiroko Nagafuchi, Norihiro Matsumura, Marina Uchida, Takayasu Ando, Kohei Yoshioka, Seido Ooka, Takahiko Sugihara, Hiroshi Miyoshi, M. Mori, Tomoyuki Okada, Masao Yamaguchi, Hiroyuki Kunishima, Motohiro Kato, Kimito Kawahata,

Contact Dermatitis and Allergies

The mechanism of allergic reactions to COVID-19 mRNA vaccines has not been clarified. Polyethylene glycol (PEG) is a potential antigen in the components of vaccines. However, there is little evidence that allergy after COVID-19 mRNA vaccination is related to PEG. Furthermore, the role of polysorbate (PS) as an antigen has also not been clarified. The objective of this study was to investigate whether PEG and PS allergies are reasonable causes of allergic symptoms after vaccination by detecting PEG-specific and PS-specific antibodies.