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HLA Genotypes and Type 1 Diabetes and Its Relationship to Reported Race/Skin Color in Their Relatives: A Brazilian Multicenter Study

2022; Multidisciplinary Digital Publishing Institute; Volume: 13; Issue: 6 Linguagem: Inglês

10.3390/genes13060972

2073-4425

Marília Brito Gomes, Luís Cristóvão Pôrto, Silva Da, Carlos Antônio Negrato, Elizabeth João Pavin, Renan Magalhães Montenegro, Sérgio Atala Dib, João Soares Felício, Deborah Conte Santos, Luiza Harcar Muniz, Rosângela Réa, Rossana Santiago de Sousa Azulay, Vandílson Pinheiro Rodrigues,

Pancreatic function and diabetes

We aimed to investigate the relationship between HLA alleles in patients with type 1 diabetes from an admixed population and the reported race/skin color of their relatives. This cross-sectional, multicenter study was conducted in public clinics in nine Brazilian cities and included 662 patients with type 1 diabetes and their relatives. Demographic data for patients and information on the race/skin color and birthplace of their relatives were obtained. Typing of the HLA-DRB1, -DQA1, and -DQB1 genes was performed. Most studied patients reported having a White relative (95.17%), and the most frequently observed allele among them was DRB1*03:01. Increased odds of presenting this allele were found only in those patients who reported having all White relatives. Considering that most of the patients reported having a White relative and that the most frequent observed allele was DRB1*03:01 (probably a European-derived allele), regardless of the race/skin color of their relatives, we conclude that the type 1 diabetes genotype comes probably from European, Caucasian ethnicity. However, future studies with other ancestry markers are needed to fill the knowledge gap regarding the genetic origin of the type 1 diabetes genotype in admixed populations such as the Brazilian.