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Association between chemosensory impairment with neuropsychiatric morbidity in post-acute COVID-19 syndrome: results from a multidisciplinary cohort study

2022; Springer Science+Business Media; Volume: 273; Issue: 2 Linguagem: Inglês

10.1007/s00406-022-01427-3

1433-8491

Rodolfo Furlan Damiano, Deusdedit Brandão Neto, João Vitor Ribeiro Oliveira, Jônatas Magalhães Santos, Julia Vallin Rodrigues Alves, Bruno Fukelmann Guedes, Ricardo Nitríni, Adriana Ladeira de Araújo, M.H.D.S.B. de Oliveira, André R. Brunoni, Richard Louis Voegels, Ricardo Ferreira Bento, Geraldo F. Busatto, Eurípedes C. Miguel, Orestes Vicente Forlenza, Fábio de Rezende Pinna, Edivaldo Utiyama, Aluísio Augusto Cotrim Segurado, Beatriz Perondi, Anna Miethke-Morais, Amanda C. Montal, Leila Suemi Harima Letaif, Solange Fusco, Marjorie F. Silva, Marcelo Cristiano Rocha, Izabel Marcílio, Izabel Cristina Rios, Fabiane Yumi Ogihara Kawano, Maria Amélia de Jesus, Esper G. Kallás, Carolina Carmo, Clarice Tanaka, Heraldo Possolo de Souza, Júlio Flávio Meirelles Marchini, Carlos Roberto Ribeiro de Carvalho, Juliana Carvalho Ferreira, Anna S. Levin, Maura Salaroli de Oliveira, Thaís Guimarães, Carolina dos Santos Lázari, Alberto José da Silva Duarte, Éster Cerdeira Sabino, Marcello Mihailenko Chaves Magri, Tarcisio E. P. Barros-Filho, Maria Cristina Peres Braido Francisco, Sílvia Figueiredo Costa,

Neuroinflammation and Neurodegeneration Mechanisms

Preliminary methodologically limited studies suggested that taste and smell known as chemosensory impairments and neuropsychiatric symptoms are associated in post-COVID-19. The objective of this study is to evaluate whether chemosensory dysfunction and neuropsychiatric impairments in a well-characterized post-COVID-19 sample. This is a cohort study assessing adult patients hospitalized due to moderate or severe forms of COVID-19 between March and August 2020. Baseline information includes several clinical and hospitalization data. Further evaluations were made using several different reliable instruments designed to assess taste and smell functions, parosmia, and neuropsychiatric disorders (using standardized psychiatric and cognitive measures). Out of 1800 eligible individuals, 701 volunteers were assessed on this study. After multivariate analysis, patients reporting parosmia had a worse perception of memory performance (p < 0.001). Moderate/severe hypogeusia was significantly associated with a worse performance on the word list memory task (p = 0.012); Concomitant moderate/severe olfactory and gustatory loss during the acute phase of COVID-19 was also significantly associated with episodic memory impairment (p = 0.006). We found a positive association between reported chemosensory (taste and olfaction) abnormalities and cognition dysfunction in post-COVID-19 patients. These findings may help us identify potential mechanisms linking these two neurobiological functions, and also support the speculation on a possible route through which SARS-CoV-2 may reach the central nervous system.