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STEREOMETRIC ANALYSIS OF GLIAL AND VASCULAR COMPONENTS IN THE MICROSTRUCTURE OF HUMAN NEOCORTEX REGIONS INVOLVED IN VISUAL-SPATIAL PERCEPTION

2022; Volume: 12; Issue: 3 Linguagem: Inglês

10.35630/2199-885x/2022/12/3.3

2199-885X

Т. А. Цехмистренко, В. Козлов, Valentina Vasilyeva, Sami Omar, Vadim Astashov, Д. К. Обухов, Nikolai Chernykh, Mohammadreza Azymi,

Neurological Disorders and Treatments

Visual-spatial perception in children and adolescents is largely determined by age-specific features of the structure and hemodynamics in the associative areas of the cerebral cortex. Aim. The aim of the study was to investigate the quantitative ratios of vascular and glial components in the oculomotor area 8 of the prefrontal cortex and the 37aс subarea of the posterior associative cortex involved in visual-spatial analysis. Methods. We studied 27 left large hemispheres of the brains in male subjects aged 10 to 17 years, grouped in annual intervals. We studied specific volumes of intracortical blood vessels and gliocytes in the external pyramidal layer on paraffin-embedded cortical slices impregnated with silver nitrate according to Peters with Nissl dyeing using a stereometric method. Results. We found that microstructural changes in the adolescent neocortex resulted in a decrease in the relative content of intracortical microvessels and an increase in the specific volume of gliocytes. The structural changes occur heterochronously: in the oculomotor area 8 of the prefrontal cortex, at 11-12 years of age, and in the subarea 37aс, at 12-13 years of age. Conclusion. The data obtained testify to a significant morpho-functional restructuring of trophic support and metabolic processes in the associative areas of the neocortex controlling visual-spatial perception.