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Increased risk of severe COVID-19 in hospitalized patients with SARS-CoV-2 Alpha variant infection: a multicentre matched cohort study

2022; BioMed Central; Volume: 22; Issue: 1 Linguagem: Inglês

10.1186/s12879-022-07508-x

1471-2334

Guillaume Martin‐Blondel, François‐Xavier Lescure, Lambert Assoumou, Charlotte Charpentier, Jean-Marc Chapplain, Thomas Perpoint, Gaspard Grouteau, Hugues Cordel, Gilles Pialoux, Jérome Pacanowski, Michaël Thy, Adeline Bauvois, Didier Laureillard, Fadia Hamrouni, Michèle Algarté-Génin, Julien Poissy, Diane Descamps, Dominique Costagliola, Guillaume Martin‐Blondel, Pierre Delobel, Gaspard Grouteau, Jean Roch Le Henaff, Vincent Mear, Sandra Lagarrigues, Alais Frelat, Thomas De Nadaï, Zara Steinmeyer, Arnaud Del Bello, Stéphanie Ruiz, Benjamine Sarton, Élise Noël-Savina, Jacques Izopet, Nathan Peiffer-Smadja, Michaël Thy, Mathilde Garé, Diane Le Pluart, François‐Xavier Lescure, C. Rioux, Laurène Deconinck, Yazdan Yazdanpanah, BenoitVisseaux, Diane Descamps, Charlotte Charpentier, Jean-Marc Chapplain, Pierre Tattevin, Thomas Perpoint, Maude Bouscambert‐Duchamp, Hodane Yonis, Paul Chabert, Hugues Cordel, Youssouf Mohamed-Kassim, Nolan Hassold, Ségolène Brichler, Julien Caliez, Thomas Rambaud, Marilucy Lopez‐Sublet, Frédéric Adnet, Gilles Pialoux, Christia Palacios, Marwa Bachir, Marine Nadal, Mathieu turpin, Antoine Parrot, Djeneba Fofana, Jérome Pacanowski, Karine Lacombe, Emmanuelle Gras, Laura Levi, Laure Surgers, Inès Devred, Nadia Valin, Thibault Chiarabini, Jean Luc Meynard, Adeline Bauvois, Clara Duran, Elyanne Gault, Jean‐Emmanuel Kahn, Elisabeth Rouveix, Guillaume Géri, Didier Laureillard, Albert Sotto, Paul Loubet, Claire Roger, Julien Poissy, Marc Lambert, Ady Assaf, Laurence Bocket, Firouzé Bani‐Sadr, Yohan N’Guyen, Juliette Romaru, Maxime Hentzien, Thomas Gabas, Amélie Chabrol, Cecilia Billiou, Philippe Menager, Christophe Billy, J.-J. Laurichesse, Fabrice Ketty N. Simba, Pauline Caraux Paz, Liliane Tinang, Agathe Bounhiol, Catherine Burnat, S. Soriot‐Thomas, Damien Basille, Jean Philippe Lanoix, Yoan Zerbib, Yoann Zerbib, Anne Pouvaret, Fanny Lanternier, H. Mascitti, Aurélien Dinh, Benjamin Davido, Philippe Lesprit, Suresnes, France, Service de Biologie Clinique Philippe Les, Éric Farfour, Mathilde Neuville, Linda Nait Allaoua, Michèle Lejaille, Nathalie De Castro, Jean‐Michel Molina, Diane Ponscarme, Mariagrazia Tateo, Geoffroy Liégeon, Ines Boussen, Pauline Huriez, André Cabié, Valentine Campana, Isabelle Calmont, Jean-Marie Turmel, Guitteaud Karine, Pierre-François Sandrine, A Marquise, Ornella Cabras, Mélanie Lehoux, Cyrille Chabartier, Vincent Dubée, Diama Ndiaye, Caroline Lefeuvre, Achille Kouatchet, Duc Thanh Nguyen, Camille Tumiotto, Pierre Sioniac, Alexandre Boyer, Jean-François Faucher, E. Desvaux, Sylvie Ranger‐Rogez, Paul Le Turnier, F. Raffi, Emmanuel Canet, Antoine Roquilly, Louise Castain, Solène Sécher, V. Mondain, Lionel Piroth, Christelle Auvray, P. Chavanet, Marielle Buisson, Sophie Mahy, François-Xavier Catherine, Clémentine Estève, Michel Duong, Carole Charles, Sandrine Gohier, Céline Schaffer, Olivier Robineau, Perrine Bortolotti, M. Pradier, François Goehringer, Alice Corbel, Jeanne Kotzyba, Kévin Alexandre, G. Béduneau, Élodie Alessandri-Gradt, M. Martinot, Simon Gravier, Ciprian Ion, Victoire de Lastours, Roza Rahli, Valérie Garrait, Laurent Richier, Mounira Smati-Lafarge, Guillemette Frémont, Pierre Louis Nivose, M. André, M. Gérin, A. Hamdi, N. Sayre, Stephanie Cossec, Sophie Alviset, Pierre Alain Billy, Marie Gousseff, E. Forestier, A. Destrem, O. Rogeaux, Alexie Bosch, Sabrina Bryant, Gaëlle Bourgeois, Ophélie Dos Santos Schaller, Marie-Christine Carret, N. Ettahar, Haciba Moudjahed, Nathalie Léone, M. Djennaoui, Nicolas Lefèbvre, Axel Ursenbach, François Danion, Yvon Ruch, Morgane Solis, Hamid Merdji, Loïc Kassègne, Fanny Pommeret, Emeline Colomba Blameble, Merad Manssouria, Annabelle Stoclin, Frank Griscelli, Sophie Deriaz, E. Oziol, Laurent Favier, Julien Obiols, Pascal Gicquel, C. Rapp, Laurence Louvet, Paul Ihout, Jean‐benoît Zabbe, Laurent Bellec, Tomasz Chroboczek, Sandrine Mégessier, Marie Lacoste, Benjamin Viala, T. Challan-Belval, C. Wackenheim, P. Letertre-Gibert, Olivier Grossi,

COVID-19 Clinical Research Studies

Abstract Background The impact of the variant of concern (VOC) Alpha on the severity of COVID-19 has been debated. We report our analysis in France. Methods We conducted an exposed/unexposed cohort study with retrospective data collection, comparing patients infected by VOC Alpha to contemporaneous patients infected by historical lineages. Participants were matched on age (± 2.5 years), sex and region of hospitalization. The primary endpoint was the proportion of hospitalized participants with severe COVID-19, defined as a WHO-scale > 5 or by the need of a non-rebreather mask, occurring up to day 29 after admission. We used a logistic regression model stratified on each matched pair and accounting for factors known to be associated with the severity of the disease. Results We included 650 pairs of patients hospitalized between Jan 1, 2021, and Feb 28, 2021, in 47 hospitals. Median age was 70 years and 61.3% of participants were male. The proportion of participants with comorbidities was high in both groups (85.0% vs 90%, p = 0.004). Infection by VOC Alpha was associated with a higher odds of severe COVID-19 (41.7% vs 38.5%—aOR = 1.33 95% CI [1.03–1.72]). Conclusion Infection by the VOC Alpha was associated with a higher odds of severe COVID-19.