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NSAIDs in sciatica (NIS): study protocol for an investigator-initiated multicentre, randomized placebo-controlled trial of naproxen in patients with sciatica

2022; Springer Science+Business Media; Volume: 23; Issue: 1 Linguagem: Inglês

10.1186/s13063-022-06441-3

1745-6215

Lars Grøvle, Eivind Hasvik, René Holst, Anne Julsrud Haugen,

Pain Mechanisms and Treatments

Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used to treat sciatica, despite insufficient evidence from placebo-controlled trials. NSAIDs may cause serious side effects; hence, there is a strong need to clarify their potential beneficial effects in patients with sciatica.