Portal de Periódicos da CAPES

Cannabis use as a factor of lower corpulence in hepatitis C-infected patients: results from the ANRS CO22 Hepather cohort

2022; BioMed Central; Volume: 4; Issue: 1 Linguagem: Inglês

10.1186/s42238-022-00138-9

2522-5782

Tangui Barré, Fabrice Carrat, Clémence Ramier, Hélène Fontaine, Vincent Di Beo, Morgane Bureau, Céline Dorival, Dominique Larrey, Elisabeth Delarocque‐Astagneau, Philippe Mathurin, Fabienne Marcellin, Ventzislava Petrov–Sanchez, Carole Cagnot, Patrizia Carrieri, Stanislas Pol, Camélia Protopopescu, Laurent Alric, Chloe Pomes, Fabien Zoulim, Marianne Maynard, Roxane Bai, Lucie Hucault, François Bailly, F. Raffi, Eric Billaud, D. Boutoille, Maeva Lefebvre, Elisabeth André‐Garnier, Paul Calès, I. Hubert, Adrien Lannes, F. Lunel, Jérôme Boursier, Tarik Asselah, Nathalie Boyer, Nathalie Giuily, Corinne Castelnau, Giovanna Scoazec, Stanislas Pol, Hélène Fontaine, Emilie Rousseaud, Anaı̈s Vallet-Pichard, Philippe Sogni, Victor de Lédinghen, Juliette Foucher, Jean‐Baptiste Hiriart, Jancell M’Bouyou, Marie Irlès-Depé, Marc Bourlière, Si Nafa Si Ahmed, Valérie Oulès, Albert Tran, Rodolphe Anty, Ève Gelsi, Régine Truchi, Dominique Thabut, Saloua Hammeche, Joseph Moussali, Xavier Causse, Barbara De Dieuleveult, Brahim Ouarani, Damien Labarrière, Nathalie Ganne‐Carrié, Véronique Grando–Lemaire, Pierre Nahon, Séverine Brulé, Betul Ulker, Dominique Guyader, Caroline Jézéquel, Audrey Brener, Anne Laligant, Aline Rabot, Isabelle Renard, François Habersetzer, Thomas F. Baumert, Michel Doffoël, Catherine Schmidt‐Mutter, Pauline Simo‐Noumbissie, Esma Razi, Jean-Pierre Bronowicki, Hélène Barraud, Mouni Bensenane, Abdelbasset Nani, Sarah Hassani-Nani, Marie-Albertine Bernard, Georges‐Philippe Pageaux, Dominique Larrey, M Mészáros, Sophie Métivier, Christophe Bureau, Thibault Morales, Jean Marie Péron, Marie Angèle Robic, Thomas Decaens, Marine Faure, Bruno Froissart, Marie‐Noëlle Hilleret, Jean–Pierre Zarski, Ghassan Riachi, Odile Goria, Fatima Paris, Hélène Montialoux, Vincent Leroy, Giuliana Amaddeo, Anne Varaut, Mélanie Simoes, Rachida Amzal, Olivier Chazouillières, Tony Andréani, Bénédicte Angoulevant, Azeline Chevance, Lawrence Serfaty, Didier Samuel, Térésa Antonini, Audrey Coilly, Jean‐Charles Duclos‐Vallée, Mariagrazia Tateo, Armand Abergel, Maud Reymond, Chanteranne Brigitte, Buchard Benjamin, Léon Muti, Claire Geist, Guillaume Conroy, Raphaëlle Riffault, Isabelle Rosa, Camille Barrault, Laurent Costes, Hervé Hagège, V. Loustaud‐Ratti, Paul Carrier, Maryline Debette‐Gratien, Philippe Mathurin, Guillaume Lassailly, Elise Lemaître, V. Canva, Sébastien Dharancy, Alexandre Louvet, Anne Minello, Marianne Latournerie, Marc Bardou, Thomas Mouillot, Louis d’Altéroche, Didier Barbereau, Charlotte Nicolas, Laure Elkrief, Anaïs Jaillais, Jérôme Gournay, Caroline Chevalier, Isabelle Archambeaud, Sarah Habès, Isabelle Portal, Moana Gelu‐Siméon, Eric Saillard, Marie-Josée Lafrance, Lucie Catherine, Fabrice Carrat, Frédéric Chau, Céline Dorival, Isabelle Goderel, Clovis Lusivika‐Nzinga, Marc-Antoine Bellance, Jonathan Bellet, Priscilla Monfalet, Jessica Chane-Teng, Sephora Bijaoui, Grégory Pannetier, François Téoulé, Jérôme Nicol, Florian Sebal, Rafika Bekhti, Carole Cagnot, Anaïs Boston, Laura Nailler, Guillaume Le Meut, Alpha Diallo, Ventzislava Petrov-Sanchez, Marc Bourlière, Jérôme Boursier, Fabrice Carrat, Patrizia Carrieri, Elisabeth Delarocque‐Astagneau, Victor de Lédinghen, Céline Dorival, Hélène Fontaine, Slim Fourati, Chantal Housset, Dominique Larrey, Pierre Nahon, Georges‐Philippe Pageaux, Ventzislava Petrov-Sanchez, Stanislas Pol, Mathias Bruyand, Linda Wittkop, Fabien Zoulim, Jessica Zucman‐Rossi, Marianne L’hennaff, Michèle Sizorn, Carole Cagnot,

Diet, Metabolism, and Disease

Patients with chronic hepatitis C virus (HCV) infection are at greater risk of developing metabolic disorders. Obesity is a major risk factor for these disorders, and therefore, managing body weight is crucial. Cannabis use, which is common in these patients, has been associated with lower corpulence in various populations. However, this relationship has not yet been studied in persons with chronic HCV infection.Using baseline data from the French ANRS CO22 Hepather cohort, we used binary logistic and multinomial logistic regression models to test for an inverse relationship between cannabis use (former/current) and (i) central obesity (i.e., large waist circumference) and (ii) overweight and obesity (i.e., elevated body mass index (BMI)) in patients from the cohort who had chronic HCV infection. We also tested for relationships between cannabis use and both waist circumference and BMI as continuous variables, using linear regression models.Among the 6348 participants in the study population, 55% had central obesity, 13.7% had obesity according to their BMI, and 12.4% were current cannabis users. After multivariable adjustment, current cannabis use was associated with lower risk of central obesity (adjusted odds ratio, aOR [95% confidence interval, CI]: 0.45 [0.37-0.55]), BMI-based obesity (adjusted relative risk ratio (aRRR) [95% CI]: 0.27 [0.19-0.39]), and overweight (aRRR [95% CI]: 0.47 [0.38-0.59]). This was also true for former use, but to a lesser extent. Former and current cannabis use were inversely associated with waist circumference and BMI.We found that former and, to a greater extent, current cannabis use were consistently associated with smaller waist circumference, lower BMI, and lower risks of overweight, obesity, and central obesity in patients with chronic HCV infection. Longitudinal studies are needed to confirm these relationships and to assess the effect of cannabis use on corpulence and liver outcomes after HCV cure.ClinicalTrials.gov identifier: NCT01953458 .