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Artigo Acesso aberto Produção Nacional Revisado por pares
BIBTEX RIS

Clinicopathological features, MCPyV status and outcomes of Merkel cell carcinoma in solid‐organ transplant recipients: a retrospective, multicentre cohort study

2022; Wiley; Volume: 36; Issue: 11 Linguagem: Inglês

10.1111/jdv.18256

ISSN

1468-3083

Autores

Carla Ferrándiz‐Pulido, Álvaro Gómez‐Tomás, B. Llombart, D. López Mendoza, Joaquim Marcoval, Stefano Piaserico, Can Baykal, Jan Nico Bouwes-Bavinck, Emöke Rácz, Jean Kanitakis, Catherine Α. Harwood, Petra Cetkovská, Alexandra Geusau, V. del Mármol, Emili Masferrer, Carmen Orte Cano, Jan Říčař, Walmar Roncalli de Oliveira, Rafael Salido‐Vallejo, E. Ducroux, M.A. Gkini, José Antonio López‐Guerrero, Heinz Kutzner, Werner Kempf, Deniz Seçkin,

Tópico(s)

Antenna Design and Analysis

Resumo

Abstract Background The proportion of Merkel cell carcinomas (MCCs) in solid‐organ transplant recipients (SOTR) harbouring Merkel cell polyomavirus (MCPyV) is unknown, as are factors affecting their outcomes. Objective To describe clinicopathological features of MCC in SOTR, investigate the tumoral MCPyV‐status and identify factors associated with tumour outcomes. Methods Retrospective, international, cohort‐study. MCPyV‐status was investigated by immunohistochemistry and polymerase chain reaction. Results A total of 30 SOTR and 44 consecutive immunocompetent patients with MCC were enrolled. SOTR were younger at diagnosis (69 vs . 78 years, P < 0.001). Thirty‐three percent of SOTR MCCs were MCPyV‐positive vs . 91% of immunocompetent MCCs ( P = 0.001). Solid‐organ transplantation was associated with an increased cumulative incidence of progression (SHR: 3.35 [1.57–7.14], P = 0.002), MCC‐specific mortality (SHR: 2.55 [1.07–6.06], P = 0.034) and overall mortality (HR: 3.26 [1.54–6.9], P = 0.002). MCPyV‐positivity and switching to an mTOR inhibitor (mTORi) after MCC diagnosis were associated with an increased incidence of progression (SHR: 4.3 [1.5–13], P = 0.008 and SHR: 3.6 [1.1–12], P = 0.032 respectively) in SOTR. Limitations Retrospective design and heterogeneity of SOTR cohort. Conclusions MCPyV appears to play a less prominent role in the aetiopathogenesis of MCC in SOTR. SOTR have a worse prognosis than their immunocompetent counterparts and switching to an mTORi after the diagnosis of MCC does not improve progression.

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