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The Staphylococcus aureus Network Adaptive Platform Trial Protocol: New Tools for an Old Foe

2022; Oxford University Press; Volume: 75; Issue: 11 Linguagem: Inglês

10.1093/cid/ciac476

1537-6591

Steven Y. C. Tong, Jocelyn Mora, Asha C Bowen, Matthew P. Cheng, Nick Daneman, Anna L. Goodman, George Heriot, Todd C. Lee, Roger Lewis, David Chien Lye, Robert K. Mahar, Julie Marsh, Anna McGlothlin, Zoe McQuilten, Susan C. Morpeth, David L. Paterson, David J. Price, Jason Roberts, James O. Robinson, Sebastiaan J. van Hal, Genevieve Walls, Steve Webb, Lyn Whiteway, Dafna Yahav, Joshua S. Davis, Nick Anagnostou, Sophia Archuleta, Eugene Athan, Lauren Barina, Emma Best, Max Bloomfield, Jennifer Bostock, Carly Botheras, Asha C Bowen, Philip N Britton, Hannah J. Burden, Anita Campbell, Hannah Carter, Matthew P. Cheng, Ka Lip Chew, Russel Lee Ming Chong, Geoffrey W. Coombs, Peter Daley, Nick Daneman, Jane C. Davies, Joshua S. Davis, Yael Dishon, Ravindra Dotel, Adrian Dunlop, Felicity Flack, Katie L. Flanagan, Hong Foo, Nesrin Ghanem‐Zoubi, Stefano Giulieri, Anna L. Goodman, Jennifer Grant, Dan Gregson, Stephen Guy, Amanda Gwee, Erica Hardy, Andrew Henderson, George Heriot, Benjamin P. Howden, Fleur Hudson, Jennie Johnstone, Shirin Kalimuddin, Dana de Kretser, Andrea Lay‐Hoon Kwa, Todd A. Lee, Amy Legg, Roger Lewis, Martin Llewelyn, Thomas Lumley, David Chien Lye, Derek R. MacFadden, Robert K. Mahar, Isabelle Malhamé, Michael Marks, Julie Marsh, Marianne Martinello, Gail Matthews, Colin McArthur, Anna McGlothlin, Genevieve McKew, Brendan McMullan, Zoe McQuilten, Eliza Milliken, Jocelyn Mora, Susan C. Morpeth, Srinivas Murthy, Clare Nourse, Matthew O’Sullivan, David L. Paterson, Mical Paul, Neta Petersiel, Lina Petrella, Sarah Pett, David J. Price, Jason Roberts, Owen Robinson, Benedict D. Rogers, Benjamin R. Saville, Matthew Scarborough, Marc H. Scheetz, Oded Scheuerman, Kevin Schwartz, Simon Smith, Tom Snelling, Marta Soares, Christine Sommerville, Andrew J. Stewardson, Neil Stone, Archana Sud, Robert Tilley, Steven Y. C. Tong, R. Brigg Turner, Jonathan Underwood, Sebastiaan J. van Hal, Lesley Voss, Genevieve Walls, Rachel Webb, Steve Webb, Lynda Whiteway, Heather L. Wilson, Terence Wuerz, Dafna Yahav,

Bacterial Identification and Susceptibility Testing

Staphylococcus aureus bloodstream (SAB) infection is a common and severe infectious disease, with a 90-day mortality of 15%-30%. Despite this, <3000 people have been randomized into clinical trials of treatments for SAB infection. The limited evidence base partly results from clinical trials for SAB infections being difficult to complete at scale using traditional clinical trial methods. Here we provide the rationale and framework for an adaptive platform trial applied to SAB infections. We detail the design features of the Staphylococcus aureus Network Adaptive Platform (SNAP) trial that will enable multiple questions to be answered as efficiently as possible. The SNAP trial commenced enrolling patients across multiple countries in 2022 with an estimated target sample size of 7000 participants. This approach may serve as an exemplar to increase efficiency of clinical trials for other infectious disease syndromes.