Portal de Periódicos da CAPES

An adaptive platform trial for evaluating treatments in patients with life‐threatening hemorrhage from traumatic injuries: Rationale and proposal

2022; Wiley; Volume: 62; Issue: S1 Linguagem: Inglês

10.1111/trf.16957

1537-2995

Juliana Tolles, Marissa Beiling, Martin A. Schreiber, Deborah J. del Junco, Jason T. McMullan, Francis X. Guyette, Henry E. Wang, Jan O. Jansen, William J. Meurer, Shraddha Mainali, Kabir Yadav, Roger Lewis,

Abdominal Trauma and Injuries

TransfusionEarly View Adaptive Platform Trial Design An adaptive platform trial for evaluating treatments in patients with life-threatening hemorrhage from traumatic injuries: Rationale and proposal Juliana Tolles, Juliana Tolles Department of Emergency Medicine, Harbor-UCLA Medical Center, Torrance, California, USA Department of Emergency Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA Berry Consultants, LLC, Austin, Texas, USASearch for more papers by this authorMarissa Beiling, Marissa Beiling Division of Trauma, Critical Care & Acute Care Surgery, Department of Surgery, Oregon Health & Science University, Portland, Oregon, USASearch for more papers by this authorMartin A. Schreiber, Martin A. Schreiber Division of Trauma, Critical Care & Acute Care Surgery, Department of Surgery, Oregon Health & Science University, Portland, Oregon, USASearch for more papers by this authorDeborah J. Del Junco, Deborah J. Del Junco Joint Trauma System, Defense Health Agency, Joint Base San Antonio Fort Sam Houston, San Antonio, Texas, USA Department of Emergency Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, USASearch for more papers by this authorJason T. McMullan, Jason T. McMullan Department of Emergency Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, USASearch for more papers by this authorFrancis X. Guyette, Francis X. Guyette Department of Emergency Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USASearch for more papers by this authorHenry Wang, Henry Wang Department of Emergency Medicine, The Ohio State University, Columbus, Ohio, USASearch for more papers by this authorJan O. Jansen, Jan O. Jansen orcid.org/0000-0001-8863-4398 Center for Injury Science, University of Alabama at Birmingham, Birmingham, Alabama, USA Division of Trauma & Acute Care Surgery, Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USASearch for more papers by this authorWilliam J. Meurer, William J. Meurer Berry Consultants, LLC, Austin, Texas, USA Department of Emergency Medicine, University of Michigan, Ann Arbor, Michigan, USA Department of Neurology, University of Michigan, Ann Arbor, Michigan, USASearch for more papers by this authorShraddha Mainali, Shraddha Mainali Department of Neurology, Virginia Commonwealth University, Richmond, Virginia, USASearch for more papers by this authorKabir Yadav, Kabir Yadav orcid.org/0000-0002-1092-9935 Department of Emergency Medicine, Harbor-UCLA Medical Center, Torrance, California, USA Department of Emergency Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USASearch for more papers by this authorRoger J. Lewis, Corresponding Author Roger J. Lewis roger@emedharbor.edu Department of Emergency Medicine, Harbor-UCLA Medical Center, Torrance, California, USA Department of Emergency Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA Berry Consultants, LLC, Austin, Texas, USA Correspondence Roger J. Lewis, Department of Emergency Medicine, Harbor-UCLA Medical Center, 1000 West Carson Street, Torrance, CA 90509, USA. Email: roger@emedharbor.eduSearch for more papers by this author Juliana Tolles, Juliana Tolles Department of Emergency Medicine, Harbor-UCLA Medical Center, Torrance, California, USA Department of Emergency Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA Berry Consultants, LLC, Austin, Texas, USASearch for more papers by this authorMarissa Beiling, Marissa Beiling Division of Trauma, Critical Care & Acute Care Surgery, Department of Surgery, Oregon Health & Science University, Portland, Oregon, USASearch for more papers by this authorMartin A. Schreiber, Martin A. Schreiber Division of Trauma, Critical Care & Acute Care Surgery, Department of Surgery, Oregon Health & Science University, Portland, Oregon, USASearch for more papers by this authorDeborah J. Del Junco, Deborah J. Del Junco Joint Trauma System, Defense Health Agency, Joint Base San Antonio Fort Sam Houston, San Antonio, Texas, USA Department of Emergency Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, USASearch for more papers by this authorJason T. McMullan, Jason T. McMullan Department of Emergency Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, USASearch for more papers by this authorFrancis X. Guyette, Francis X. Guyette Department of Emergency Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USASearch for more papers by this authorHenry Wang, Henry Wang Department of Emergency Medicine, The Ohio State University, Columbus, Ohio, USASearch for more papers by this authorJan O. Jansen, Jan O. Jansen orcid.org/0000-0001-8863-4398 Center for Injury Science, University of Alabama at Birmingham, Birmingham, Alabama, USA Division of Trauma & Acute Care Surgery, Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USASearch for more papers by this authorWilliam J. Meurer, William J. Meurer Berry Consultants, LLC, Austin, Texas, USA Department of Emergency Medicine, University of Michigan, Ann Arbor, Michigan, USA Department of Neurology, University of Michigan, Ann Arbor, Michigan, USASearch for more papers by this authorShraddha Mainali, Shraddha Mainali Department of Neurology, Virginia Commonwealth University, Richmond, Virginia, USASearch for more papers by this authorKabir Yadav, Kabir Yadav orcid.org/0000-0002-1092-9935 Department of Emergency Medicine, Harbor-UCLA Medical Center, Torrance, California, USA Department of Emergency Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USASearch for more papers by this authorRoger J. Lewis, Corresponding Author Roger J. Lewis roger@emedharbor.edu Department of Emergency Medicine, Harbor-UCLA Medical Center, Torrance, California, USA Department of Emergency Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA Berry Consultants, LLC, Austin, Texas, USA Correspondence Roger J. Lewis, Department of Emergency Medicine, Harbor-UCLA Medical Center, 1000 West Carson Street, Torrance, CA 90509, USA. Email: roger@emedharbor.eduSearch for more papers by this author First published: 22 June 2022 https://doi.org/10.1111/trf.16957Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Early ViewOnline Version of Record before inclusion in an issue RelatedInformation