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SARS-CoV-2-specific T cell memory with common TCRαβ motifs is established in unvaccinated children who seroconvert after infection

2022; Cell Press; Volume: 55; Issue: 7 Linguagem: Inglês

10.1016/j.immuni.2022.06.003

1097-4180

Louise C. Rowntree, Thi H. O. Nguyen, Łukasz Kedzierski, Melanie R. Neeland, Jan Petersen, Jeremy Chase Crawford, Lilith F. Allen, E. Bridie Clemens, Brendon Y. Chua, Hayley A. McQuilten, Anastasia A. Minervina, Mikhail V. Pogorelyy, Priyanka Chaurasia, Hyon‐Xhi Tan, Adam K. Wheatley, Xiaoxiao Jia, Fatima Amanat, Florian Krammer, E. Kaitlynn Allen, Sabrina Sonda, Katie L. Flanagan, Jaycee Jumarang, Pia S. Pannaraj, Paul V. Licciardi, Stephen J. Kent, Katherine Bond, Deborah A. Williamson, Jamie Rossjohn, Paul G. Thomas, Shidan Tosif, Nigel W. Crawford, Carolien E. van de Sandt, Katherine Kedzierska,

Immune Cell Function and Interaction

As the establishment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific T cell memory in children remains largely unexplored, we recruited convalescent COVID-19 children and adults to define their circulating memory SARS-CoV-2-specific CD4